| 冠心病合并2型糖尿病患者血浆脂蛋白a水平与冠脉病变的关系 |
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| 引用本文： | 于向东,万征,张文娟,林青,李晓春,蔡衡,李永乐.冠心病合并2型糖尿病患者血浆脂蛋白a水平与冠脉病变的关系[J].天津医药,2011,39(10):921-923. |
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| 作者姓名： | 于向东 万征 张文娟 林青 李晓春 蔡衡 李永乐 |
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| 作者单位： | 300052,天津医科大学总医院心内科 |
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| 摘 要： | 目的:探讨冠心病(CAD)合并2型糖尿病(DM)患者血浆脂蛋白(a)Lp(a)]水平与冠状动脉(冠脉)狭窄程度及范围之间的关系。方法:163例经冠状动脉造影(CAG)证实为CAD的2型DM患者按冠脉狭窄程度分中度(n=19)和重度(n=144)狭窄组,按病变范围分为单支(31例)、双支(48例)和多支(84例)病变组,54例无冠心病患者作为对照组,分别测量和比较各组Lp(a)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A-(IApoA-I)及载脂蛋白B(ApoB)水平。结果:中、重度狭窄组的Lp(a)水平高于对照组,中度狭窄组与重度狭窄组之间的Lp(a)水平差异无统计学意义。单支、双支、多支病变组Lp(a)水平高于对照组,多支病变组的Lp(a)水平高于单支、双支病变组,各组间TC、TG、HDL-C、LDL-C、ApoA-I、ApoB水平差异均无统计学意义。多元回归分析显示Lp(a)水平为冠脉狭窄程度和范围的危险因素。结论:Lp(a)水平可作为2型DM合并CAD患者冠脉病变严重性的评价指标之一。
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| 关 键 词： | 脂蛋白(A) 冠心病 糖尿病 2型 冠状血管造影术 线性模型 危险因素 |
Correlation between Lipoprotein(a) Concentration and Severity of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus |
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| YU Xiangdong,WAN Zheng,ZHANG Wenjuan,LIN Qing,LI Xiaochun,CAI Heng,LIYongle.Correlation between Lipoprotein(a) Concentration and Severity of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus[J].Tianjin Medical Journal,2011,39(10):921-923. |
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| Authors: | YU Xiangdong WAN Zheng ZHANG Wenjuan LIN Qing LI Xiaochun CAI Heng LIYongle |
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| Affiliation: | YU Xiangdong,WAN Zheng,ZHANG Wenjuan,LIN Qing,LI Xiaochun,CAI Heng,LI Yongle Department of Cardiology,General Hospital of Tianjin Medical University,Tianjin 300052,China |
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| Abstract: | Objective: To observe the correlation of lipoprotein (a)Lp(a)] level and the extent, and severity of coronary artery lesions in coronary artery disease (CAD) patients with type 2 diabetes mellitus (DM). Methods: A total of 163 patients with angiographically documented CAD were divided into two groups including moderate stenosis group (n=19) and severe stenosis group (n=114) according to the severity of coronary artery lesion. The patients were divided into three groups including mono-vessel group (n=31), b... |
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| Keywords: | lipoprotein(a) coronary disease diabetes mellitus type 2 coronary angiography linear models risk factors |
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