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| (Z)-4-氯-2-羟亚胺基乙酰乙酸乙酯的合成 | |
| 引用本文： | 程清蓉,刘志雄,李翔,喻宗沅.(Z)-4-氯-2-羟亚胺基乙酰乙酸乙酯的合成[J].精细化工中间体,2006,36(4):54-56. |
| 作者姓名： | 程清蓉 刘志雄 李翔 喻宗沅 |
| 作者单位： | 1. 武汉工程大学,化工与制药学院,湖北省新型反应器与绿色化学工艺重点实验室,湖北,武汉,430074 2. 吉首大学,化学化工学院,湖南,吉首,416000 3. 湖北省化学研究院,湖北,武汉,430073 |
| 摘 要： | 采用4-氯乙酰乙酸乙酯为原料,对(Z)-4-氯-2-羟亚胺基乙酰乙酸乙酯的合成条件进行了研究,确定了优化条件:反应温度5℃、反应时间4h、亚硝酸乙酯气体与4-氯乙酰乙酯的摩尔比n(ONOC2H5)∶n(ClCH2COCH2CO2C2H5)=1.4∶1。优化条件下产物收率约96%。 |
| 关 键 词： | 4-氯乙酰乙酸乙酯 (Z)-4-氯-2-羟亚胺基乙酰乙酸乙酯 肟化反应 合成 |
| 文章编号： | 1009-9212(2006)04-0054-03 |
| 收稿时间： | 2006-03-31 |
| 修稿时间： | 2006年3月31日 |
Synthesis of Ethyl 4-Chloro-3-oxo-2-(syn)-hydroxyiminoacetate |
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| CHENG Qing-rong,LIU Zhi-xiong,LI Xiang,YU Zong-yuan.Synthesis of Ethyl 4-Chloro-3-oxo-2-(syn)-hydroxyiminoacetate[J].Fine Chemical Intermediates,2006,36(4):54-56. | |
| Authors: | CHENG Qing-rong LIU Zhi-xiong LI Xiang YU Zong-yuan |
| Affiliation: | 1. School of Chemical Engineering and Pharmacy, Wuhan Institute of Chemical Technology, Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology, Wuhan430074, China; 2 . College of Chemistry and Chemical Engineering, Jishou University, Jishou41600, China; 3. Hubei Research Institute of Chemistry, Wuhan 430073, China |
| Abstract: | Synthetic technology of ethyl 4-chloro-3-oxo-2-(syn)-hydroxy-iminoacetate was studied using ethyl 4-haloacetoacetates as raw material. The optimal conditions for the reaction were obtained as following:reaction time 4 h,reaction temperature 5℃ and the molar ratio of reactants (ONOC2H5 : ClCH2COCH2CO2C2H5)1.4 : 1. Under the optimal conditions,the yield of ethyl 4-chloro-3-oxo-2- (syn) -hydroxyiminoacetate was about 96%. |
| Keywords: | ethyl 4-haloacetoacetates ethyl 4-chloro-3-oxo-2-(syn)-hydroxyiminoacetate oximation synthesis |
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