Evidence that helodermin, a newly extracted peptide from Gila monster venom, is a member of the secretin/VIP/PHI family of peptides with an original pattern of biological properties |
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| Authors: | P Robberecht M Waelbroeck J P Dehaye J Winand A Vandermeers M C Vandermeers-Piret J Christophe |
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| Affiliation: | Department of Biochemistry and Nutrition, Medical School, Université Libre de Bruxelles, Bld de Waterloo 115, B-1000 Brussels, Belgium |
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| Abstract: | Helodermin, a newly isolated peptide from the venom of Gila monster (Heloderma suspectum) was shown to stimulate the adenylate cyclase activity of rat pancreatic membranes as efficiently as secretin and VIP. It also increased cyclic AMP levels and inhibited [125I]VIP binding in rat pancreatic acini. Finally, helodermin activated adenylate cyclase in membranes from rat heart, rat brain, and human heart, showing properties analogous yet distinct from those of secretin, VIP and PHI. |
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| Keywords: | Gila monster venom Helodermin Secretin Vasoactive intestinal peptide Bombesin Adenylate cyclase VIP, vasoactive intestinal peptide PHI, peptide having an N-terminal histidine and a C-terminal isoleucine amide |
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