| 缺氧／复氧对兔肾动脉内皮依赖性舒张功能的影响 |
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| 引用本文： | 于立新,龙村,丰贵文.缺氧／复氧对兔肾动脉内皮依赖性舒张功能的影响[J].第一军医大学学报,2003,23(9):925-928. |
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| 作者姓名： | 于立新 龙村 丰贵文 |
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| 作者单位： | [1]第一军医大学南方医院肾移植科，广东广州510515 [2]协和医科大学阜外心血管病医院麻醉与体外循环实验室，北京100037 |
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| 摘 要： | 目的 探讨缺氧／复氧对肾动脉内皮依赖性一氧化氮(NO)和内皮衍性超极化因子(EDHF)途径舒张功能的影响。方法 采用器官槽法，以兔肾动脉环为研究对象，首先抑制PGI2舒张途径，然后再分别抑制NO和EDHF舒张途径，对给与血管环以缺氧／复氧处理，观察缺氧／复氧分别对NO和EDHF舒张途径的影响。结果 缺氧／复氧使NO途径的内皮依赖性舒张功能减退．而缺氧／复氧对EDHF途径的内皮依赖性舒张功能无变化。结论 缺氧／复氧导致兔肾血管内皮衍性NO途径的舒张损伤．而对EDHF途径的舒张无影响。
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| 关 键 词： | 缺氧 复氧 肾动脉内皮依赖性舒张功能 大血管手术 肾移植 肾脏血管重建 |
Effect of hypoxia-reoxygenation on endothelium-dependent relaxation of rabbit renal artery] |
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| Gui-wen Feng,Li-xin Yu,Cun Long.Effect of hypoxia-reoxygenation on endothelium-dependent relaxation of rabbit renal artery][J].Journal of First Military Medical University,2003,23(9):925-928. |
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| Authors: | Gui-wen Feng Li-xin Yu Cun Long |
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| Affiliation: | Department of Kidney Transplantation, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. |
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| Abstract: | OBJECTIVE: To investigate the effect of hypoxia-reoxygenation on of endothelium-dependent NO and endothelium-derived hyperpolarizing factor (EDHF) relaxation of. METHODS: The organ chamber technique was employed to study rabbit renal artery rings. By inhibiting the PGI2 relaxation pathway with hypoxia-reoxygenation of the renal artery rings, followed by inhibition of NO and EDHF relaxation pathways respectively, the effects of hypoxia-reoxygenation on NO and EDHF relaxation were observed. RESULTS: Hypoxia-reoxygenation decreased the endothelial NO relaxation of rabbit renal rings, but the endothelial EDHF relaxation. CONCLUSION: Hypoxia-reoxygenation may injure endothelium-derived NO relaxation, but not the endothelium-derived EDHF relaxation of rabbit renal rings. |
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