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| 经胃灌入高氧液对油酸型急性肺损伤家兔的治疗效果 | |
| 引用本文： | 徐瑞芬,冯旭阳,刘蕊,张惠,徐礼鲜,王凤娟.经胃灌入高氧液对油酸型急性肺损伤家兔的治疗效果[J].临床麻醉学杂志,2009,25(2). |
| 作者姓名： | 徐瑞芬 冯旭阳 刘蕊 张惠 徐礼鲜 王凤娟 |
| 作者单位： | 1. 第四军医大学口腔医院麻醉科,西安市,710032 2. 第四军医大学西京医院心脏内科 3. 第四军医大学口腔医院颌面外科,西安市,710032 |
| 摘 要： | 目的 研究经胃灌人高氧液(HO)对油酸型急性肺损伤(ALI)家兔的治疗作用.方法 以复方氯化钠为基液制备HO.将1 8只家兔随机均分为油酸致伤组(A组)、HO治疗组(B组)和正常对照组(C组).A、B组均经耳缘静脉注入油酸0.06 ml/kg建立ALI模型,C组注入等量生理盐水.B组于注射油酸30 min时经胃灌入HO 20 ml/kg,A、C组灌入等量复方氯化钠.各组分别在ALI模型制备前(0min)、注射油酸后30、60、120 min经右颈外动脉抽血进行血气分析,并测定肺水含量、肺体比值及病理榆查.结果 与C组相比,人组PaO2,PaCO2明显降低(P＜0.01),肿水含量、肺体比值及肺损伤评分明、显增高(P＜0.01).镜下见肺灶性出血,间质、肺泡水肿,大量炎性细胞浸润.B组经HO治疗后迅速提升PaO2.PaCO2(P＜0.05),减轻肺水肿(P＜0.01).结论 经胃灌人HO对油酸型ALI家兔有治疗作用. |
| 关 键 词： | 高氧液 急性肺损伤 血气分析 |
Therapeutic effect of hyperoxia solution on oleic acid-induced acute lung injury in rabbits |
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| Abstract: | Objective To investigate the effect of hyperoxia solution (HO) taken orally on acute lung injury(ALI) induced by oleic acid in rabbits. Methods Eighteen rabbits were randomly divided into three groups with 6 rabbits each:oleic acid group (group A), hyperoxia solution group(group B) and control group(group C).ALI model was established in group A and group B by injected oleic acid 0.06ml/kg,while rabbits in group C were given salt liquid.HO 20ml/kg was perfused via stomach in group B 30min after the oleic aci... |
| Keywords: | Hyperoxia solution Acute lung injury Blood gas analysis |
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