| 2-羟基-1-萘酚醛缩2-氨基苯并噻唑铜配合物的合成及其与DNA作用的光谱研究 |
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| 引用本文： | 杨欢春,杨天林,王丽娟.2-羟基-1-萘酚醛缩2-氨基苯并噻唑铜配合物的合成及其与DNA作用的光谱研究[J].光谱实验室,2010,27(6):2124-2129. |
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| 作者姓名： | 杨欢春 杨天林 王丽娟 |
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| 作者单位： | [1]宁夏大学能源化工重点实验室,银川市西夏区贺兰山西路785号750021 [2]宁夏疾病预防控制中心,银川市兴庆区胜利南街470号750001 |
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| 基金项目： | 教育部科学基金重点项目，宁夏高校科学研究基金 |
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| 摘 要： | 合成了2-羟基-1-萘酚醛缩2-氨基苯并噻唑铜配合物,通过IR、UV、元素分析、摩尔电导及热分析,对此化合物进行了结构表征。在pH 7.22的Tris-HCl缓冲溶液中,采用紫外光谱、荧光光谱和粘度法研究了2-羟基-1-萘酚醛缩2-氨基苯并噻唑铜配合物与ct-DNA的相互作用。结果表明该化合物以插入式与ct-DNA键合。
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| 关 键 词： | 希夫碱 铜配合物 小牛胸腺脱氧核糖核酸 |
Synthesis of Schiff Base Condensed from 2-Hydroxy-1-Naphthaide-Hyde with 2-Amino-Benzothiazole and Its Copper Complexes and Spectral Study on Its Interaction with ct-DNA |
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| YANG Huan-Chun,YANG Tian-Lin,WANG Li-Juan.Synthesis of Schiff Base Condensed from 2-Hydroxy-1-Naphthaide-Hyde with 2-Amino-Benzothiazole and Its Copper Complexes and Spectral Study on Its Interaction with ct-DNA[J].Chinese Journal of Spectroscopy Laboratory,2010,27(6):2124-2129. |
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| Authors: | YANG Huan-Chun YANG Tian-Lin WANG Li-Juan |
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| Affiliation: | (Key Laboratory of Energy Resources and Chemical Engineering, Ningxia University, Yinchuan 750021, P. R. China; Ningxia Centers for Diseases Prevention and Control,Yinchuan 750001 ,P. R. China) |
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| Abstract: | Schiff base condensed from 2-hydroxy-l-naphthalde-hyde with 2-amino-benzothiazole and its copper complexes were synthesized, and its structure has been characterized by IR, UV, TG-DTA, elements analysis and molar conductance analysis. The interaction between its complexes and ct-DNA has been studied by electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurement in buffer solution of Tris-HCl（pH 7.22）. All of the results indicated that the interaction of the complexes with ct-DNA was intercalation. |
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| Keywords: | Schiff Base Copper Complex ct-DNA |
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