缬沙坦联合百令胶囊治疗高血压肾病的临床效果观察

目的观察缬沙坦联合百令胶囊治疗高血压肾病的临床效果。方法选择本院52例高血压肾病患者，随机分成缬沙坦组（A组）和缬沙坦联合百令胶囊组（B组），观察两组治疗前后临床症状及实验室指标（24h尿蛋白定量、尿素氮、血肌酐、血清胱抑素C）改变情况。结果治疗8周后，A、B组总有效率分别为46．15％、73．08％；两组24h尿蛋白定量及血清胱抑素C水平均较治疗前下降（P〈0．05），且治疗后B组明显低于A组（P〈0．05），而两组治疗后尿素氮、血肌酐水平较治疗前下降（P〈0．05），但治疗后组问差异无统计学意义（P〉0．05）。结论缬沙坦联合百令胶囊可有效治疗高血压肾病，且联合用药效果优于单独用药，值得应用。

Clinical effect of valsartan combined with bailing capsule in treatment of hypertensive nephropathy

Objective To observe the therapeutic effect of valsartan combined with bailing capsule in treatment of hy- pertensive nephropathy. Methods 52 cases of patients with hypertensive nephropathy were randomly divided into group A （valsartan） and group B （valsartan combined with bailing capsule）. The clinical symptoms and the laboratory indexes （24 h urinary protein excretion, serum urea nitrogen, serum creatinine and serum cystatin C） were observed before and after treatment. Results After eight weeks treatment, the total effective rate of group A and group B was 46.15% and 73.08% respectively, 24 h urinary protein excretion and serum cystatin C were all significantly decreased in the two groups（P〈0.05）, and the two indexes of group B were lower than group A（P〈0.05）. Serum urea nitrogen and serum cre- atinine were both decreased after treatment, but there was no significant difference between two groups （P〉0.05）. Con- clusion Valsartan combined with bailing capsule has good therapeutic effect for hypertensive nephropathy, and the therapeutic effect of combined therapy is better than single medication, worthy of application.