Ezrin蛋白在鼻咽癌组织中的表达及其对鼻咽癌远处转移的影响

目的：探讨Ezrin蛋白在鼻咽癌组织中的表达情况及其对鼻咽癌远处转移的影响。方法采用免疫组织化学方法检测Ezrin蛋白在98例鼻咽癌患者（观察组）和37例慢性鼻咽炎患者（对照组）组织中的表达情况。并分析鼻咽癌患者的详细临床分期和病理特点，跟踪随访治疗过程中发生复发和转移的情况。结果观察组98例患者中，69例（70．4％）呈现Ezrin蛋白阳性表达；对照组37例患者中，仅有4例（10．8％）呈现Ezrin蛋白阳性表达；两组Ezrin蛋白阳性率差异有统计学意义（χ2＝38．42，P＝0．00）。通过对观察组中不同Ezrin蛋白表达强度患者的远处转移情况比较发现，Ezrin的强阳性（＋＋＋）与肿瘤的远处转移密切相关，Ezrin蛋白阳性（＋＋）、（＋＋＋）表达组与阴性（-）和/或弱阳性（＋）表达组患者比较，肿瘤转移率明显偏高（均P＜0.05）。结论 Ezrin蛋白在鼻咽癌患者组织中呈现高表达情况，并且Ezrin蛋白的阳性表达与鼻咽癌的远处转移有关。

Expression of Ezrin protein in nasopharyngeal carcinoma and its effect in metastasis of nasopharyngcal carcinoma

Objective To study the Ezrin protein in nasopharyngeal carcinoma expression and its effects on metastasis of nasopharyngeal carcinoma .Methods Expression of Ezrin protein was detected by immunohistochemical method in 98 cases with nasopharyngeal carcinoma and 37 cases of chronic nasopharyngitis tissues were analyzed . Clinical staging and pathological characteristics , recurrence and metastasis following treatment in the process of 98 patients with nasopharyngeal carcinoma were observed .Results 98 cases of patients with nasopharyngeal carcino-ma research group,69 cases（70.4%） patients were positive expression of Ezrin protein .The control group nasopha ryngeal mucositis of patients ,only 4 patients showed positive expression of Ezrin protein ,the rate of positive expression was 10.8%.The differences between the two groups compared with the positive rate of Ezrin significantly （χ2 =38.42,P=0.00）.By comparison on strength of patients with distant metastases of different expression of Ezrin in study group,closely related to Ezrin strong positive and tumor metastasis , Ezrin protein （ ＋＋） and （ ＋＋＋） expression group and negative （-） and weak positive （＋） expression group compared with patients ,tumor migration rate was significantly higher（all P＆lt;0.05）.Conclusion Ezrin protein shows significantly higher expression in tis-sues of patients with nasopharyngeal carcinoma ,the positive expression of Ezrin protein in nasopharyngeal carcinoma and with the distant metastasis .