Naturally occurring bioactive Cyclobutane-containing (CBC) alkaloids in fungi,fungal endophytes,and plants |
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| Affiliation: | 1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, Düsseldorf 40225, Germany;2. Department of Organic Chemistry, Higher Teachers'' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon;3. Institute of Inorganic and Structural Chemistry, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, Düsseldorf 40225, Germany;4. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China |
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| Abstract: | This article focuses on the occurrence and biological activities of cyclobutane-containing (CBC) alkaloids obtained from fungi, fungal endophytes, and plants. Naturally occurring CBC alkaloids are of particular interest because many of these compounds display important biological activities and possess antitumour, antibacterial, antimicrobial, antifungal, and immunosuppressive properties. Therefore, these compounds are of great interest in the fields of medicine, pharmacology, medicinal chemistry, and the pharmaceutical industry. Fermentation and production of CBC alkaloids by fungi and/or fungal endophytes is also discussed. This review presents the structures and describes the activities of 98 CBC alkaloids. |
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| Keywords: | Fungi Fungal endophytes Plant Alkaloids Activities Cyclobutane |
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