| 人参茎叶总皂甙对实验性小鼠生殖细胞遗传物质损伤的影响 |
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| 引用本文： | 朱玉琢,邢沈阳,孙凯,刘念稚. 人参茎叶总皂甙对实验性小鼠生殖细胞遗传物质损伤的影响[J]. 吉林大学学报(医学版), 1994, 0(3) |
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| 作者姓名： | 朱玉琢 邢沈阳 孙凯 刘念稚 |
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| 作者单位： | 长春铁路医院 |
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| 摘 要： | 本文采用小鼠精原细胞姐妹染色单体互换（ＳＣＥ）实验方法，研究了人参茎叶总皂甙（ＧＮＳ）对丝裂霉素Ｃ（ＭＭＣ）引起的小鼠精原细胞遗传物质损伤的影响。结果表明，ＧＮＳ不能诱发小鼠精原细胞ＳＣＥ，而且在腹腔注射ＭＭＣ的同时给予ＧＮＳ，可使ＭＭＣ诱发的小鼠精原细胞ＳＣＥ频率明显降低。为此，我们认为ＧＮＳ对小鼠生殖细胞遗传物质具有保护作用。
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| 关 键 词： | 人参皂甙／药理学，丝裂霉素／药理学，精原细胞／药物作用，姐妹染色单体互换／药物作用 |
Influence of Ginsenosides from stem and leaves on theexperimental damage of genetic materials in mouse genital cells |
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| Zhu Yuzhuo,Xing Shenyang,Liu Nianzhi,Sun Kai. Influence of Ginsenosides from stem and leaves on theexperimental damage of genetic materials in mouse genital cells[J]. Journal of Jilin University: Med Ed, 1994, 0(3) |
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| Authors: | Zhu Yuzhuo Xing Shenyang Liu Nianzhi Sun Kai |
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| Abstract: | with sister chromatid exchange(SCE) test, influences of ginsenosides from stemand leaves(GNS)on damage of genetic materials induced by mitomycin C(MMC)in mousespermatogonia were studied. the results showed that GNS could not induce SCE in mouse sper-matogonia, but the frequencies of SCE induced by MMC in mouse spermatogonia were reducedsignificantly if GNS and MMC were given ip simultaneously。 Thus, we consider that GNS has aprotective effect on genetic materials in genital cells |
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| Keywords: | Ginseng Saponins/PD mitomycins/PD sister chromatid exchange/DE sper- matogonia/DE |
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