Antioxidant effect ofSalvia miltiorrhiza |
| |
| Authors: | Hye Sook Kang Hae Young Chung Jee Hyung Jung Sam Sik Kang Jae Sue Choi |
| |
| Affiliation: | (1) Department of Food and Life Science, Pukyong National University, 608-737 Pusan, Korea;(2) Department of Pharmacy, Pusan National University, 609-735 Pusan, Korea;(3) Natural Products Research Institute, Seoul National University, 110-460 Seoul, Korea |
| |
| Abstract: | A strong antioxidant activity, which was measured by the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl(DPPH)
radical, was detected in the methanol extract ofSalvia miltiorrhiza Bunge (Labiatae). By activity-directed fractionation, compounds 1 and 2 were isolated as antioxidant principles ofS. miltiorrhiza. Compounds 1 and 2 were identified as dimethyl lithospermate and 3-(3,4-dihydroxyphenyl)lactamide, respectively, on the basis
of spectral data. The radical scavenging effect of compounds 1 and 2 on DPPH radical exceeded that of L-ascorbic acid which
is a well known antioxidant. These two compounds also showed prominent inhibitory activity against free radical generation
in dichlorofluorescein (DCF) method and cytoprotective effect againstt-BHP in cultured liver cell. |
| |
| Keywords: | Salvia miltiorrhiza dimethyl lithospermate 3-(3 4-dihydroxyphenyl)lactamide antioxidant activity |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
