冠状动脉内高危易损斑块识别的多模态成像进展

冠状动脉粥样硬化斑块破裂或侵蚀引起的血栓形成造成心肌梗死事件的发生。了解斑块是如何从稳定型转变为危及生命的高危易损斑块的过程并寻求有效的早期干预是临床亟需解决的问题。目前，临床中使用的腔内影像学技术可以识别斑块的形态特征，但不能可靠预测哪些稳定型斑块会转变为高危易损斑块发生破裂继发心肌梗死。本文从高危斑块单模态成像进展、血管内分子成像到多模态血管内成像技术的进展作相关整理，并总结近年来多项评估高危易损斑块的研究，对冠脉内高危易损斑块识别的多模态成像在临床转化的可能性和潜力进行综述。

Advances in Multimodality Intravascular Imaging for Identification of High-risk Vulnerable Plaques in Coronary Arteries

Coronary thrombosis caused by rupture or erosion of coronary atherosclerotic plaques results in myocardial infarction events. Understanding how plaques change from stable to life-threatening, high-risk vulnerable plaques and seeking effective intervention is a pressing need. Currently, intra-cavitary imaging technology used in clinical practice allows visualization of detailed morphological features of plaques, however, it is not reliable to predict which type of stable plaques will transform into high-risk vulnerable plaques or rupture secondary to myocardial infarction. This article collates advances in single-modality imaging of high-risk plaques, intravascular molecular imaging to the progress of multimodality intravascular imaging, and summarizes studies in recent years to assess high-risk and vulnerable plaques. The possibility and potential of multimodal imaging for plaque identification in clinical transformation are reviewed.