| 组胺致肺损伤犬的呼吸力学评估 |
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| 引用本文： | 孙喜庆,吴兴裕.组胺致肺损伤犬的呼吸力学评估[J].第四军医大学学报,1994,15(4):255-257. |
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| 作者姓名： | 孙喜庆 吴兴裕 |
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| 作者单位： | SUN Xi-Qing，WU Xing-Yu and ZHANG Li-Fan Laboratory of Applied and Systems Physiology |
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| 摘 要： | 本实验通过比较组胺引起的肺与呼吸顺应性、导纳的改变，以验证组胺引起的肺反应可由呼吸系统反应正确评估。结果表明，静脉滴注组胺可引起肺顺应性（ＣＬ），呼吸系统顺应性（Ｃｒｓ），肺导纳（ＧＬ），呼吸系统导纳（Ｇｒｓ），Ｐａｏ２及显降低（Ｐ＜０．０５），Ｐａｃｏ２及Ｑｓ／Ｑｔ显升高（Ｐ＜０．０５）。在组胺滴注时，ＣＬ与Ｃｒｓ（ｒ＝０．８５，Ｐ＜０．０１），ＧＬ与Ｇｒｓ（ｒ＝０．９５，Ｐ＜０．０１）均呈
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| 关 键 词： | 呼吸力学 肺力学 组胺 肺损伤 |
Assessment of respiratory mechanics in dogs with histamine-induced lung injury |
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| SUN Xi-Qing,WU Xing-Yu and ZHANG Li-Fan Laboratory of Applied and Systems Physiology.Assessment of respiratory mechanics in dogs with histamine-induced lung injury[J].Journal of the Fourth Military Medical University,1994,15(4):255-257. |
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| Authors: | SUN Xi-Qing WU Xing-Yu and ZHANG Li-Fan Laboratory of Applied and Systems Physiology |
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| Abstract: | The aim of this study was to demonstrate that the pulmonary response to histamine can be correct-ly appreciated from the respiratory response.The results showed that histamine infusion produced a marked decrease in pulmonary and respiratory system compliances(CL and Crs),pulmonary and respiratory system conductances(GL and Grs),Pao2 and pH,and a marked increase in Paco2 and Qs/Qt.Highly significant cor- relations were found between CL and Crs(r=0.95,P<0.01),and between GL and Grs(r=0.95 ,P< 0.01) during histamine infusion.It is suggested that the response of the respiratory system to histamine infu-sion provides a simple and accurate assessment of the pulmonary response. |
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| Keywords: | respiratory mechanics lung mechanics histamine respiratory system compliance |
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