Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, P.R. China;2. Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, P.R. China;3. Tianhe Agricultural Group, Longquan, P.R. China;4. Leicester School of Pharmacy, De Montfort University, Leicester, UK;5. Department of Biomedical Engineering, Key Laboratory of Ministry of Education, Zhejiang University, Hangzhou, P.R. China