| 联合去甲氧柔红霉素治疗急性白血病的临床研究 |
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| 引用本文： | 李刚,王宝燕,翟欣辉,赵文理,武佐鹏,郑成云,王岐山,邢佩霓,李梅生.联合去甲氧柔红霉素治疗急性白血病的临床研究[J].白血病．淋巴瘤,1998(4). |
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| 作者姓名： | 李刚 王宝燕 翟欣辉 赵文理 武佐鹏 郑成云 王岐山 邢佩霓 李梅生 |
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| 作者单位： | 陕西省人民医院，西安医科大学第一附属医院 |
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| 摘 要： | 采用以４－去甲氧基柔红霉素（ＩＤＡ）为主组成的联合化疗方案，治疗３３例初发和复发的急性白血病，其中急性淋巴细胞白血病（ＡＬＬ）７例，急性非淋巴细胞白血病（ＡＮＬＬ）２６例。结果：总有效率７０％。初治２３例ＡＮＬＬ患者，完全缓解（ＣＲ）１６例，部分缓解（ＰＲ）２例，有效率为７９％。５例初治ＡＬＬ患者，４例ＣＲ，１例ＰＲ。而复发的２例ＡＬＬ和３例ＡＮＬＬ患者均未缓解。ＩＤＡ主要副作用表现为骨髓抑制及心脏毒性。认为以ＩＤＡ组成联合化疗方案治疗初发的急性白血病具有较好的疗效
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| 关 键 词： | 4－去甲氧基柔红霉素 白血病 急性 化疗 |
APPLICATION OF THE IDARUBICIN IN THE TREATMENT OF ACUTE LEUKEMIA |
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| Li Gang,Wang Baoyan,Zhai Xinghui,et al Shanxi Provincial Hospital.APPLICATION OF THE IDARUBICIN IN THE TREATMENT OF ACUTE LEUKEMIA[J].Journal of Leukemia & Lymphoma,1998(4). |
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| Authors: | Li Gang Wang Baoyan Zhai Xinghui Shanxi Provincial Hospital |
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| Abstract: | patients with acute leukemia(AL)were treated with the chemotherapy including idarubicin from Sept. of 1993 to July of 1998. There were 7 patients with acute lymphocytic leukemia(ALL)and 26 patients with acute non lymphocytic leukemia(ANLL).The results showed that the total remission rate was 70%.18 patients achieved complete remission(CR) and partial remission (PR) in 23 initial patients with ANLL. The total remission rate was as high as 79%.4 and 1 in 5 patients with initial ALL got CR and PR respectively. While, in this article there was no effect on 2 patients with relapsed ALL and 3 with relapsed ANLL.The major side effects encountered were marrow suppresion and heart toxicity. |
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| Keywords: | Idarubicin Acute leukemia Chemotherapy |
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