| 壮骨止痛方提取物对去势骨质疏松症雌鼠血清E_2、BGP水平的影响 |
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| 引用本文： | 范娟娟,莫新民,张国民,甘国兴,刘仕杰.壮骨止痛方提取物对去势骨质疏松症雌鼠血清E_2、BGP水平的影响[J].山东中医药大学学报,2011(2). |
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| 作者姓名： | 范娟娟 莫新民 张国民 甘国兴 刘仕杰 |
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| 作者单位： | 湖南中医药大学; |
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| 基金项目： | 2008年国家自然科学基金面上项目; 2006年武汉市科技攻关计划项目; 湖南省中医药大学中医内科学重点学科资助项目(编号:30873291编号:20065009138-05) |
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| 摘 要： | 目的:观察壮骨止痛方提取物对去势骨质疏松症雌鼠血清雌激素(E2)和骨钙素(BGP)的影响。方法:60只3月龄雌性SD大鼠随机分为正常组(A组)、假手术组(B组)、模型对照组(C组)、壮骨止痛方提取物组(D组)四组,15只/组,除正常组及假手术组外,其余组去势(去卵巢)后建立绝经后骨质疏松症模型大鼠,假手术组则去除卵巢周边相应体积的脂肪。大鼠皆灌胃13周后处死取材,测定血清中E2、BGP的含量并观察股骨头病理组织形态学变化。结果:D组大鼠E2水平明显升高,同时血清BGP的水平降低,与C组比较,有显著性差异(P<0.05,P<0.01)。病理形态学镜下观察C组骨小梁稀疏、破坏,骨髓腔扩大,骨小梁密度明显下降,A组与B组骨小梁分布均匀,股骨骨小梁密度正常,D组骨小梁密度分布比较均匀,骨小梁密度基本恢复正常。结论:壮骨止痛方提取物不仅能促进雌激素分泌,而且可以通过调节BGP以降低骨转换率,减少骨量丢失,达到抗骨质疏松的目的。
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| 关 键 词： | 骨质疏松症 绝经后 骨钙素 雌激素 去卵巢 |
Effects of extracts from Zhuanggu Zhitong recipe on serum E_2 and BGP of ovariectomized female rats with osteoporosis |
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| FAN Juan-juan,MO Xin-min,ZHANG Guo-min,GAN Guo-xing,LIU Shi-jie.Effects of extracts from Zhuanggu Zhitong recipe on serum E_2 and BGP of ovariectomized female rats with osteoporosis[J].Journal of Shandong University of Traditional Chinese Medicine,2011(2). |
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| Authors: | FAN Juan-juan MO Xin-min ZHANG Guo-min GAN Guo-xing LIU Shi-jie |
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| Affiliation: | FAN Juan-juan,MO Xin-min,ZHANG Guo-min,GAN Guo-xing,LIU Shi-jie(Hunan University of Traditional Chinese Medicine,Changsha 410007,China) |
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| Abstract: | Objective:To observe effects of extracts from Zhuanggu Zhitong recipe(ZGZTR) on the serum estrogen(E2) and osteocalcin(BGP) of ovariectomized female rats with osteoporosis.Methods:Total 60 female SD rats,aged 3 months,were randomly divided into four groups:the normal group(A group),sham operation group(B group),model group(C group),ZGZTR group(D group).There were 15 rats in each group.Postmenopausal osteoporosis rats were established by removing ovaries in C and D groups.B group just be removed the correspo... |
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| Keywords: | osteoporosis postmenopausal osteocalcin estrogen ovariectomized |
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