| 表观调控与神经干细胞分化 |
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| 引用本文： | 汤海亮,朱剑虹. 表观调控与神经干细胞分化[J]. 神经科学通报, 2007, 23(4): 241-248. DOI: 10.1007/s12264-007-0036-8 |
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| 作者姓名： | 汤海亮 朱剑虹 |
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| 作者单位： | [1]复旦大学附属华山医院神经外科,上海200040 [2]复旦大学上海医学院医学神经生物学国家重点实验室,上海200032 |
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| 基金项目： | 国家重点基础研究发展计划(973计划);国家自然科学基金;上海市科委科技计划 |
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| 摘 要： | 神经干细胞是当前神经科学领域的研究热点。最近的研究显示表观调控与神经干细胞的分化关系密切,而且为神经干细胞的移植治疗提供可能的细胞来源。表观调控是指在基因的DNA序列未改变的情况下,基因功能发生可遗传的变化而导致细胞表型发生改变,主要机制包括DNA甲基化、组蛋白修饰、基因印迹、染色体重组以及非编码小RNA等。本综述就表观调控对神经干细胞分化作用的最新进展作一回顾。
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| 关 键 词： | 干细胞 表遗传 神经元限制性沉默元件 基因印记 非编码RNA |
| 文章编号： | 1673-7067（2007）04-0241-08 |
| 修稿时间： | 2007-03-14 |
Epigenetics and neural stem cell commitment |
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| Hai-Liang Tang,Jian-Hong Zhu. Epigenetics and neural stem cell commitment[J]. Neuroscience Bulletin, 2007, 23(4): 241-248. DOI: 10.1007/s12264-007-0036-8 |
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| Authors: | Hai-Liang Tang Jian-Hong Zhu |
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| Affiliation: | Department of Neurosurgery, Fudan University, Huashan Hospital, Shanghai 200040, China National Key Laboratory for Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai 200032, China |
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| Abstract: | Neural stem cell is presently the research hotspot in neuroscience. Recent progress indicates that epigenetic modulation is closely related to the self-renewal and differentiation of neural stem cell. Epigenetics refer to the study of mitotical/meiotical heritage changes in gene function that cannot be explained by changes in the DNA sequence. Major epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, genomic imprinting, and non-coding RNA. In this review, we focus on the new insights into the epigenetic mechanism for neural stem cells fate. |
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| Keywords: | H19 stem cells epigenesis neuron restrictive silencer element genomic imprinting H19 non-coding RNA |
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