丹参活性成分及制剂改善脑侧支循环及促进血管生成的药理作用研究进展

丹参Salvia miltiorrhiza作为临床上常用的活血化瘀药，其药理作用广泛，尤其在治疗脑血管病上方面效果良好，其主要活性成分和制剂均具有良好的改善脑侧支循环及促进血管生成的药理作用。通过对改善脑侧支循环和血管生成的丹参活性成分（丹参素类和丹参酮类）和丹参类制剂（丹参注射剂如注射用丹参多酚酸、注射用丹参多酚酸盐、丹红注射液及口服制剂如复方丹参滴丸、复方丹参片、复方丹参颗粒等）的药理作用进行综述，为临床合理用药以及与侧支循环和血管生成相关的脑血管病治疗提供依据。

Research progress in pharmacological effects of active components and preparations of Salvia miltiorrhiza on improving cerebral collateral circulation and promoting angiogenesis

Salvia miltiorrhiza, is a common using clinical drug to invigorate the circulation of blood and dispersing blood stasis, has a wide range of pharmacological effects, especially effective in the treatment of cerebrovascular diseases, and its main active ingredients and preparations have good pharmacological effects on improving cerebral collateral circulation and promoting angiogenesis. By reviewing the pharmacological effects of the active ingredients, which to improve cerebral collateral circulation and angiogenesis (tanshinin and tanshinone) and salvia preparations (danshen injections such as Danshen Polyphenolic Acid for Injection, Danshen Polyphenolate for Injection, Danshen Injection and oral preparations such as compound Danshen Drop Pills, Compound Danshen Tablets, Compound Danshen Granules, etc.), this paper provides a basis for clinical rational drug using and the treatment of cerebrovascular diseases related to collateral circulation and angiogenesis.