1990-2019年中国儿童青少年哮喘疾病负担分析题录

目的分析1990-2019年我国1～19岁儿童青少年哮喘疾病负担及其变化趋势, 为优化儿童青少年哮喘的健康管理提供依据。方法利用2019年全球疾病负担中国分省研究结果, 比较1990年和2019年中国儿童青少年哮喘的发病、患病、死亡和伤残调整寿命年(DALY), 描述1990-2019年我国各省份儿童青少年哮喘疾病负担的分布情况。结果 2019年我国儿童青少年哮喘发病人数、患病人数和死亡人数分别为215.41万95%不确定区间(UI):137.80万～319.76万]、869.07万(95%UI:579.83万～1 312.65万)和78(95%UI:63～106), 发病率、患病率和死亡率分别为718.23/10万(95%UI:459.47/10万～1 066.17/10万)、2 897.73/10万(95%UI:1 933.33/10万～4 376.75/10万)和0.03/10万(95%UI:0.02/10万～0.04/10万)。相较于1990年, 2019年儿童青少年哮喘发病率和患病率均上升变化率为3.28%(95%UI:-0.66%～7.27%)和0.58%(95%UI:...

Disease burden of asthma among children and adolescents in China, 1990-2019

Objective To analyze the burden of asthma disease and its trends among children and adolescents aged 1 to 19 years in China during 1990-2019 and to provide a basis for optimizing the health management strategy of asthma in children and adolescents. Methods Data based on the 2019 Global Burden of Disease Study for China were used to compare the incidence, prevalence, death, and disability adjusted life year (DALY) of children and adolescents with asthma in 1990 and 2019 and to describe the distribution of the disease burden of asthma in children and adolescents by provincial administrative regions in China from 1990 to 2019. Results In 2019, the number of incidence, prevalence, and death were 2 154 10095% uncertainty interval (UI):1 378 000-3 197 600], 8 690 700 (95%UI:5 798 300-13 126 500), and 78 (95%UI:63-106), respectively. The incidence, prevalence, and mortality were 718.23/100 000 (95%UI:459.47/100 000-1 066.17/100 000), 2 897.73/100 000 (95%UI:1 933.33/100 000-4 376.75/100 000), and 0.03/100 000 (95%UI:0.02/100 000-0.04/100 000), respectively. The incidence and prevalence increasedchange rate:3.28% (95%UI:-0.66%-7.27%) and 0.58% (95%UI:-3.33%-4.18%)], respectively, and the mortality decreasedchange rate:-92.17% (95%UI:-94.97%- -85.78%)] compared with 1990. The age-standardized DALY rate decreased by 17.91% from 1990 to 2019. On the whole, the rate of decline showed less in the eastern and more in the western areas. The three provinces with the most significant decreases were Yunnan Province (-53.15%), Guizhou Province (-45.46%), and Tibet Autonomous Region (-35.61%). Hong Kong Special Administrative Region (0.65%) was the only region showing an increase in disease burden. The age-standardized DALY rate for asthma in children and adolescents ranged from 103.26/100 000 to 144.35/100 000 by the province in 2019. The province with the highest age-standardized DALY rate was Hong Kong Special Administrative Region (144.35/100 000), and the lowest was Heilongjiang Province (103.26/100 000). The asthma disease burden was higher in male children and adolescents than in females. Conclusions Incidence and prevalence of asthma increased, and mortality decreased in children and adolescents in China from 1990-2019. The age-standardized DALY rate also decreased, but there were regional disparities in the rate of decline. The disease burden was more significant in males than in females. Research and prevention efforts for asthma in children and adolescents should be continued.