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| 康柏西普不同给药方案治疗DME的安全性和疗效评估 | |
| 引用本文： | 孟婷,孙洪岩,罗彬,王晶,汪丽玉,高亚莉,蒋莉,王君,邓铤明,曾爱能,罗小玲,杨明明. 康柏西普不同给药方案治疗DME的安全性和疗效评估[J]. 国际眼科杂志, 2023, 23(1): 138-141 |
| 作者姓名： | 孟婷 孙洪岩 罗彬 王晶 汪丽玉 高亚莉 蒋莉 王君 邓铤明 曾爱能 罗小玲 杨明明 |
| 作者单位： | 中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院,中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院,中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院,中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院; 中国贵州省贵阳市,贵州医科大学,,中国广东省湛江市,广东医科大学,中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院,中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院,中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院,中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院,中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院,中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院,中国广东省深圳市人民医院 暨南大学第二临床医学院 南方科技大学第一附属医院 |
| 基金项目： | 国家自然科学基金项目(No.82000768); 深圳市基础研究专项(深圳市自然科学基金)面上项目(No.JCYJ20210324113808023) |
| 摘 要： | 目的:评估康柏西普采用连续3次每月注射后改用按需治疗方案(3+PRN)和连续5次每月注射后改用按需治疗方案(5+PRN)治疗糖尿病性黄斑水肿(DME)的安全性和疗效。方法:回顾性病例对照研究。选取2019-12/2020-06期间于我院就诊的DME患者51例92眼纳入研究，据治疗方案分为3+PRN组(26例48眼)和5+PRN组(25例44眼)。治疗后至少随访12mo,观察两组患者最佳矫正视力(BCVA)和中心凹视网膜厚度(CMT)的变化情况，玻璃体腔注药次数及眼部不良事件发生率。结果:随访12mo, 3+PRN组、5+PRN组患者平均注药次数无差异(7.24±0.91次vs 7.56±1.04次，P=0.117)。治疗后3、6、9、12mo,两组患者BCVA和CMT均较治疗前改善(均P<0.05),且治疗后6、9、12mo, 5+PRN组患者BCVA和CMT均优于3+PRN组(均P<0.05)。随访期间，两组患者均未发生严重不良事件，两组患者眼部不良事件总发生率均为27%,所有不良事件给予对症处理后均好转。结论:康柏西普3+PRN和5+PRN治疗方案均能安全有效地治疗DM... |
| 关 键 词： | 康柏西普 糖尿病性黄斑水肿(DME) 按需治疗 最佳矫正视力 中心凹视网膜厚度 注射次数 |
| 收稿时间： | 2022-04-21 |
| 修稿时间： | 2022-12-06 |
Safety and efficacy of different loading doses followed by pro re nata regimens of Conbercept in the treatment of diabetic macular edema |
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| Ting Meng,Hong-Yan Sun,Bin Luo,Jing Wang,Li-Yu Wang,Ya-Li Gao,Li Jiang,Jun Wang,Ting-Ming Deng,Ai-Neng Zeng,Xiao-Ling Luo and Ming-Ming Yang. Safety and efficacy of different loading doses followed by pro re nata regimens of Conbercept in the treatment of diabetic macular edema[J]. International Eye Science, 2023, 23(1): 138-141 | |
| Authors: | Ting Meng Hong-Yan Sun Bin Luo Jing Wang Li-Yu Wang Ya-Li Gao Li Jiang Jun Wang Ting-Ming Deng Ai-Neng Zeng Xiao-Ling Luo Ming-Ming Yang |
| Affiliation: | Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China,Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China,Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China,Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China; Guizhou Medical University, Guiyang 550001, Guizhou Province, China,Guangdong Medical University, Zhanjiang 524023, Guangdong Province, China,Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China,Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China,Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China,Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China,Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China,Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China and Shenzhen People''s Hospital;the Second Clinical Medical College of Jinan University;the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518003, Guangdong Province, China |
| Abstract: | AIM: To evaluate the efficacy and safety of different Conbercept treatment on diabetic macular edema(DME)with 3+PRN and 5+PRN. METHODS: Retrospective case-control study. A total of 51 patients(92 eyes)with DME who were treated in our hospital during December 2019 and June 2020 were included, and they were divided into 3+PRN group with 26 cases(48 eyes)and 5+PRN group with 25 cases(44 eyes). All patients received monthly follow-up for 12mo and the changes of best-corrected visual acuity(BCVA)and central macular thickness(CMT), the number of intravitreal injections and the occurrence of complications were compared and observed in the two groups. RESULTS:After follow-up for 12mo, there was no difference in the average injection times between the 3+PRN group and the 5+PRN group(7.24±0.91 times vs. 7.56±1.04 times, P=0.117). The BCVA and CMT of the two groups improved at 3, 6, 9, and 12mo after treatment compared with those before treatment(all P<0.05), and the BCVA and CMT of the 5+PRN group were better than those of the 3+PRN group at 6, 9, and 12mo after treatment(all P<0.05). During the follow-up period, no serious adverse events occurred in the two groups of patients, and the total incidence of ocular adverse events in the two groups was 27%. All adverse events were improved after symptomatic treatment. CONCLUSION: Both the 3+PRN and 5+PRN treatment strategy of Conbercept can treat DME safely and effectively, the total times of injection were comparable. However, the BCVA and CMT improved more in the 5+PRN group than that in 3+PRN group. |
| Keywords: | Conbercept diabetic macular edema(DME) pro re nata best corrected visual acuity central macular thickness times of injection |
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