Effect of preparation conditions on the properties of microspheres prepared using an emulsion-solvent extraction process |
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Authors: | Harri Heiskanen,Peter Denifl,Pä ivi Pitkä nen,Markku Hurme |
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Affiliation: | 1. Department of Biotechnology and Chemical Technology, Aalto University School of Science and Technology, P.O. Box 6100, FIN-02015 HUT, Finland;2. Borealis Polymers Oy, P.O. Box 330, FIN-06101 Porvoo, Finland |
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Abstract: | Methylaluminoxane microspheres were prepared using a hydrocarbon-in-perfluorocarbon-emulsion solvent extraction process. The effect of the preparation conditions on the size of the microspheres was investigated. As expected, the size of the microspheres decreased with increasing stirring speed. At low surfactant concentrations the size of the microspheres was independent of the surfactant concentration. However, the size of the microspheres decreased as the surfactant concentration was further increased. The size of the microspheres was not only affected by the surfactant concentration but also by the volume ratio of the dispersed phase to the continuous phase. At a low volume ratio of the phases the effect of the surfactant on the size of the microspheres was larger than the effect of the increased volume ratio of the phases. At high volume ratios of the phases the effect of the volume ratio of phases on the size of the microspheres became more significant than the effect of the surfactant. A slow solidification increased the formation of non-spherical microspheres. |
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Keywords: | Microsphere Emulsification Particle size distribution Solvent extraction |
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