| 静脉用丙种球蛋白治疗新生儿重症感染对细胞免疫功能的影响 |
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| 引用本文： | 王晓鸥,杨国贤,李晓静,屈青,黄少虹,章崇杰. 静脉用丙种球蛋白治疗新生儿重症感染对细胞免疫功能的影响[J]. 重庆医学, 1995, 0(2) |
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| 作者姓名： | 王晓鸥 杨国贤 李晓静 屈青 黄少虹 章崇杰 |
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| 作者单位： | 成都市儿童医院!610017(王晓鸥，杨国贤，李晓静，屈青，黄少虹)，华西医科大学免疫教研室!610041(章崇杰) |
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| 摘 要： | 应用静脉注丙球(IVIG),配合抗生素(An)治疗重症感染新生儿12例,在观察疗效及不良反应的同时,通过检测患儿治疗前后T细胞亚群及白细胞介素Ⅱ(IL-2)产生水平的变化,观察IVIG对细胞免疫功能的影响。结果显示:患儿CD_3~+、CD_4~+、CD_8~+细胞及IL-2产生水平均明显低于正常同龄新生儿。经IVIG+An及单用An治疗后,T细胞各亚群及IL-2水平均明显增高。IVIG组与An组比较,诒疗后IVIG组CD_4~+细胞明显高于An组,IL-2水平也较An组为高,但无统计学意义。疗效观察,中毒症状及原发病体征好转消失时间IVIG组较An组明显缩短。本文还就IVIG对细胞免疫功能影响的可能机制进行了讨论。
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| 关 键 词： | 静脉用丙种球蛋白 新生儿重症感染 T细胞亚群 IL-2 |
Effect of intravenous immunoglobulin on cellular immunity in treating neonatal severe infection |
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| Wand Xiafou et alChengdu children's hospital,Chendu. Effect of intravenous immunoglobulin on cellular immunity in treating neonatal severe infection[J]. Chongqing Medical Journal, 1995, 0(2) |
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| Authors: | Wand Xiafou et alChengdu children's hospital Chendu |
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| Affiliation: | Wand Xiafou et alChengdu children's hospital,Chendu 610017 |
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| Abstract: | 12 case neontes with severe infection were observed the change of cellular immunity before and af ter treatment with antibiotic(An) + intravenous immunoglobulin(IVIg). The results showed that(1). The T cell subset(CD3+ ,CD4+ ,CD8+ .cells; .CD4/CD8 &. IL-2 production level of neonate with severe infection were significantly lower than the normal controls. (2)After treatment the T cell subset and IL-2 level were significantly increased. CD4+ cell of group treated with An+IVIg wsa higher than that of the group treated with An alone. (3). The toxicity &. sign of group treated with An + IVIg were improvement and remission quicker than that of the group treated with An alone. |
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| Keywords: | Intravenous immunoglobulin Neonatal severe infection IL-2 T cell subset |
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