| α-溴-4-取代苯酮的合成 |
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| 引用本文： | 胡艾希,贺丽敏,史文革,范占煌,蒋英明.α-溴-4-取代苯酮的合成[J].精细化工,2004,21(3):235-237. |
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| 作者姓名： | 胡艾希 贺丽敏 史文革 范占煌 蒋英明 |
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| 作者单位： | 1. 湖南大学,化学化工学院,湖南,长沙,410082
2. 湖南大学,化学化工学院,湖南,长沙,410082;南华大学,湖南,衡阳,421001 |
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| 摘 要： | 通过4 取代苯酮的α 溴化反应合成医药中间体α 溴 4 取代苯酮。选择溴化铜在乙酸乙酯和氯仿混合溶剂中对4 甲氧基苯乙酮、4 羟基苯乙酮、4 羟基苯丙酮、4 羟基苯戊酮、4 苄氧基苯乙酮、4 苄氧基苯丙酮和4 苄氧基苯戊酮溴化2～3h,分别得α 溴 4 甲氧基苯乙酮、α 溴 4 羟基苯乙酮、α 溴 4 羟基苯丙酮、α 溴 4 羟基苯戊酮、α 溴 4 苄氧基苯乙酮、α 溴 4 苄氧基苯丙酮和α 溴 4 苄氧基苯戊酮,收率82 6%～97 5%。α 溴化产物的结构经1HNMR,IR确证。
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| 关 键 词： | α-溴-4-甲氧基苯乙酮 α-溴-4-羟基苯酮 α-溴-4-苄氧基苯酮 溴化铜 α-溴化反应 |
| 文章编号： | 1003-5214(2004)03-0235-03 |
Synthesis of α-Bromo-4-substituted Phenones |
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| HU Ai-xi,HE Li-min,SHI Wen-ge.Synthesis of α-Bromo-4-substituted Phenones[J].Fine Chemicals,2004,21(3):235-237. |
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| Authors: | HU Ai-xi HE Li-min SHI Wen-ge |
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| Affiliation: | HU Ai-xi~1,HE Li-min~1,SHI Wen-ge~ |
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| Abstract: | α -Bromo- 4-methoxyacetophenone, α -bromo- 4-hydroxyacetophenone, α -bromo- 4-hydroxypropiophenone, α -bromo- 4-hydroxyvalerophenone, α -bromo- 4-benzyloxyacetophenone, α -bromo- 4-benzyloxypropiophenone and α -bromo- 4-benzyloxyvalerophenone were synthesized by α -bromination of 4-methoxyacetophenone,4-hydroxyacetophenone,4-hydroxypropiophenone,4-hydroxyvalerophenone,4-benzyloxyacetophenone,4-benzyloxypropiophenone and 4-benzyloxyvalerophenone respectively with cupric bromide in AcOEt-CHCl_3 in 82.6%～97.5 % yield.Structures of the products were confirmed by IR and ~1HNMR. |
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| Keywords: | α -bromo- 4-methoxyacetophenone α -bromo- 4-hydroxyphenone α -bromo- 4- benzyloxyphenone cupric bromide α - bromination |
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