| 甲啶铂在玻碳电极上的电化学行为及其与DNA相互作用研究 |
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| 引用本文： | 叶丽清,闫莉莉,向明武,高云涛,贝玉祥.甲啶铂在玻碳电极上的电化学行为及其与DNA相互作用研究[J].贵金属,2014,35(1):63-69. |
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| 作者姓名： | 叶丽清 闫莉莉 向明武 高云涛 贝玉祥 |
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| 作者单位： | 云南民族大学化学与生物技术学院;民族药资源化学国家民委-教育部重点实验室;昆明贵研药业有限公司; |
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| 基金项目： | 云南省创新团队计划(2011HC008);云南省高校科技创新团队计划项目(2011UY09) |
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| 摘 要： | 采用循环伏安法(CV)和差分脉冲伏安法(DPV),研究了甲啶铂在多壁碳纳米管-离子液体修饰玻碳电极(MWNTs-ODMIM]PF6/GCE)上的电化学行为,建立了甲啶铂的测定方法;以紫外-可见光谱法和电化学方法相结合,研究了甲啶铂与DNA的嵌插结合作用。结果表明:甲啶铂在MWNTs-ODMIM]PF6/GCE上有一对氧化还原峰,氧化峰电位Epa与还原峰电位Epc分别为-0.07 V、-0.36 V,峰电位之差为ΔE=0.29 V,Ipa/Ipc=1.11。在优化条件下,甲啶铂的氧化峰电流与其浓度在2.66~532μmol/L范围内成良好的线性关系(r=0.9994),检出限为1.33μmol/L。方法操作简便,准确可靠、灵敏度高,可用于甲啶铂含量的直接测定。
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| 关 键 词： | 分析化学 甲啶铂 多壁碳纳米管 离子液体 玻碳电极 电化学行为 伏安法 |
| 收稿时间： | 2013/8/1 0:00:00 |
Study on the Electrochemical Behavior of Picoplatin and Interaction of Picoplatin with DNA at Glassy Carbon Electrode |
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| YE Liqing,YAN Lili,XIANG Mingwu,GAO Yuntao and BEI Yuxiang.Study on the Electrochemical Behavior of Picoplatin and Interaction of Picoplatin with DNA at Glassy Carbon Electrode[J].Precious Metals,2014,35(1):63-69. |
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| Authors: | YE Liqing YAN Lili XIANG Mingwu GAO Yuntao and BEI Yuxiang |
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| Affiliation: | Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, College of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China;Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, College of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China;Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, College of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China;Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, College of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China;Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China |
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| Abstract: | |
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| Keywords: | analytical chemistry picoplatin multi-walled carbon nanotubes ionic liquids glassy carbon electrode electrochemical behavior voltammetry |
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