| 溴代二羟基二苯醚类化合物的合成与抑菌活性研究 |
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| 引用本文： | 金洪,陈鸶,侯若彤,王玉良,陈淑华,杨志荣.溴代二羟基二苯醚类化合物的合成与抑菌活性研究[J].有机化学,2006,26(10):1424-1428. |
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| 作者姓名： | 金洪 陈鸶 侯若彤 王玉良 陈淑华 杨志荣 |
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| 作者单位： | 1. 四川大学化学学院,成都,610064
2. 四川大学生命科学学院,成都,610064 |
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| 基金项目： | 国家自然科学基金(No.20272038)资助项目. |
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| 摘 要： | 设计并合成了7个新的溴代2,2'-, 2,4-'和4,4'-二羟基二苯醚; 所有这些化合物的结构均经1H NMR, MS, IR和元素分析所证实; 新化合物的结构避免了现有二苯醚杀菌剂在生产和使用过程中有可能生成高毒性二噁类化合物的缺点; 并选择8种有害菌对合成的新的溴代二羟基二苯醚进行了抑菌活性测试, 结果表明它们对所测试菌种具有很好的抑制活性, 与目前国内外广泛使用的广谱抗菌剂三氯新的抑菌活性相当.
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| 关 键 词： | 溴代二羟基二苯醚 合成 抑菌活性 |
| 收稿时间： | 12 15 2005 12:00AM |
| 修稿时间： | 04 24 2006 12:00AM |
Study on the Synthesis and Antimicrobial Activities of Brominated Dihydroxy Diphenyl Ethers |
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| JIN, Hong,CHEN, Si,HOU, Ruo-Tong,WANG, Yu-Liang,CHEN, Shu-Hua,YANG, Zhi-Rong.Study on the Synthesis and Antimicrobial Activities of Brominated Dihydroxy Diphenyl Ethers[J].Chinese Journal of Organic Chemistry,2006,26(10):1424-1428. |
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| Authors: | JIN Hong CHEN Si HOU Ruo-Tong WANG Yu-Liang CHEN Shu-Hua YANG Zhi-Rong |
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| Affiliation: | 1. College of Chemistry, Sichuan University, Chengdu 610064;2. College of Life Science, Sichuan University, Chengdu 610064 |
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| Abstract: | Seven brominated dihydroxy diphenyl ethers have been designed and synthesized. Structures of new compounds have been confirmed by 1H NMR, MS, IR spectra and elemental analysis. These new com-pounds have the advantage in avoiding producing the severe toxicity of dioxins in the course of manufactur-ing and using. The bioactivity testing showed that these compounds possessed good antimicrobial activities toward the tested bacterium. |
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| Keywords: | brominated dihydroxy diphenyl ether synthesis antimicrobial activity |
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