| CD_4~+CD_(25)~+调节性T细胞与肿瘤免疫治疗的新进展 |
| |
| 引用本文： | 翟海龙,雷丹琼,程震勇,胡敏. CD_4~+CD_(25)~+调节性T细胞与肿瘤免疫治疗的新进展[J]. 时珍国医国药, 2010, 21(3) |
| |
| 作者姓名： | 翟海龙 雷丹琼 程震勇 胡敏 |
| |
| 作者单位： | 1. 黄石理工学院·医学院,湖北,黄石,435003
2. 华中科技大学药学院,湖北,武汉,430074 |
| |
| 摘 要： | CD_4~+CD_(25)~+调节性T细胞(CD_4~+CD_(25)~+ regulatory T cells, CD_4~+CD_(25)~+ Tregs)可抑制机体对肿瘤的免疫应答,导致不利于肿瘤患者的对肿瘤的免疫耐受.以降低CD_4~+CD_(25)~+Tregs作用,增强对肿瘤的免疫应答为新策略的肿瘤免疫治疗探索已有初步进展.方法 包括去除CD_4~+CD_(25)~+Tregs、单克隆抗体、蛋白分子转移、阻断Tregs的迁移和分化、逆转Tregs的分化、阻断Tregs的功能、疫/瘤苗、将Tregs调控与其他治疗模式相组合、提升抑制效应细胞的阈值.
|
| 关 键 词： | CD_4~+CD_(25)~+调节性T细胞 肿瘤 免疫治疗 |
New Advance in CD_4~+CD_(25)~+ Regulatory T Cells and Tumor Immunnotherapy |
| |
| ZHAI Hai-long,LEI Dan-qiong,CHENG Zhen-yong,HU Min. New Advance in CD_4~+CD_(25)~+ Regulatory T Cells and Tumor Immunnotherapy[J]. Lishizhen Medicine and Materia Medica Research, 2010, 21(3) |
| |
| Authors: | ZHAI Hai-long LEI Dan-qiong CHENG Zhen-yong HU Min |
| |
| Affiliation: | ZHAI Hai-long1,LEI Dan-qiong1,CHENG Zhen-yong2,HU Min1(1.School of Medicine,Huangshi Institute of Technology,Huangshi,Hubei,China 435003,China,2.School of Pharmacology,Huazhong University of Science , Technology Wuhan,430074 China) |
| |
| Abstract: | CD4+CD25+ regulatory T cells(CD4+CD25+ Tregs) can suppress the useful immune response against tumors,which lead to immune tolerance to tumors in tumor patients.The tumor immunotherapy based on the new strategy which decreases the function of CD4+CD25+ Tregs and enhances the immune response against tumors has been explored.The methods were consisted of the depletion of CD4+CD25+Tregs,monoclonal antibodies,protein molecule transfer,blocking Tregs trafficking and differentiation,subverting Tregs differentiatio... |
| |
| Keywords: | CD_4~+CD_(25)~+ regulatory T cells Tumor Immunnotherapy |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
