长链非编码RNA的竞争性内源RNA调控模式在动脉粥样硬化中的研究进展

动脉粥样硬化是一种缓慢进行性的血管炎症性病变。越来越多的研究表明长链非编码RNA(lncRNA)作为竞争性内源RNA(ceRNA)与微小RNA(miRNA)结合,通过ceRNA网络调控靶基因信使RNA(mRNA)分子的表达水平和功能,在动脉粥样硬化的病理生理过程中发挥重要作用。lncRNA、miRNA和mRNA之间的互作调控机制复杂。本文综述了lncRNA-miRNA-mRNA调控网络在动脉粥样硬化发病机制中的调控关系,阐述该调控网络在内皮细胞功能障碍、血管平滑肌细胞表型转化、巨噬细胞激活以及脂质代谢异常等病变中的重要作用,为动脉粥样硬化临床诊疗提供新思路。

The roles of long noncoding RNA as the competitive endogenous RNA in atherosclerosis

Atherosclerosis is a chronic vascular inflammation process. Emerging studies have shown that long non-coding RNA (lncRNA) can interact with microRNA as the competitive endogenous RNA (ceRNA), and regulate the expression and function of its target genes,which plays an important role in the pathogenesis of atherosclerosis. The novel regulatory mechanisms underlying the crosstalk among lncRNA, microRNA and mRNA are complex. This review comprehensively summarized the regulatory relationship of lncRNA-microRNA-mRNA axis in the pathophysiological processes of atherosclerosis, and highlighted the important role of this axis involved in endothelial cell dysfunction, vascular smooth muscle cell phenotype transformation, macrophage activation and lipid metabolism abnormality, aiming to provide new targets for clinical treatment of atherosclerotic diseases.