Prognostic Significance of Phosphatase of Regenerating Liver-3 Expression in Ovarian Cancer |
| |
Authors: | Tingting Ren Beihai Jiang Xiaofang Xing Bin Dong Lirong Peng Lin Meng Huiyu Xu Chengchao Shou |
| |
Affiliation: | (1) Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, 52 Fu, cheng Road, Beijing, 100, 142, C, hina;(2) Core facility of Beijing Cancer Hospital & Institute, Beijing, China;(3) Present address: Musculoskeleted Tumor Center, Peking University People’s Hospital, Beijing, 100044, China; |
| |
Abstract: | Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in several human cancers and associated with tumor progression,
invasion and metastasis. However, the correlation between PRL-3 expression and clinical outcome in ovarian cancer has not
been studied. In the present study, we investigated the expression of PRL-3 in 119 ovarian cancers and 30 normal ovarian tissues
by immunohistochemistry with an anti-PRL-3 mouse monoclonal antibody 3B6, and analyzed its relationship with clinicopathologic
factors and survival. The results demonstrated that PRL-3 expression was significantly higher in ovarian cancers compared
to normal ovarian tissues (P < 0.001). PRL-3 expression is not correlated with patient age, menstruation, tumor size, histological
type, residual tumor, or other clinical findings. The patients with PRL-3-positive tumors had a significant poor prognosis
than those with PRL-3-negative tumors. Univariate analysis identified PRL-3 expression as a poor outcome predictor (HR 1.925,
95% CI, 1.046–3.544, P = 0.035). Multivariate analysis indicated that PRL-3 expression was an independent prognostic factor
of borderline significance (HR 1.695, 95% CI, 0.914–3.145, P = 0.094). Our results suggest that PRL-3 may serve as a valuable
marker for diagnosis of ovarian cancer and as a potential independent prognostic factor for ovarian cancer. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|