| 利用单粒子追踪技术研究活细胞内肌球蛋白的运输模式 |
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| 引用本文： | 梁璋仪,徐宁,关英华,张幼怡,赵新生. 利用单粒子追踪技术研究活细胞内肌球蛋白的运输模式[J]. 化学物理学报, 2007, 20(4): 445-448 |
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| 作者姓名： | 梁璋仪 徐宁 关英华 张幼怡 赵新生 |
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| 作者单位： | 北京分子科学国家实验室, 分子动态与稳态结构国家重点实验室，北京大学化学与分子工程学院化学生物学系，北京100871,北京大学第三医院心血管研究所，北京100083,北京分子科学国家实验室, 分子动态与稳态结构国家重点实验室，北京大学化学与分子工程学院化学生物学系，北京100871,北京大学第三医院心血管研究所，北京100083,北京分子科学国家实验室, 分子动态与稳态结构国家重点实验室，北京大学化学与分子工程学院化学生物学系，北京100871 |
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| 摘 要： | 利用单个粒子追踪技术研究?1A肾上腺素受体在活细胞内的转运．?1A肾上腺素受体在细胞内沿微丝骨架的转运表现为步进式模式，平均步长与体外对肌球蛋白的研究相一致．对不同时间分辨率下数据的模拟分析结果表明，肌球蛋白在细胞内运输内涵体的单步动力学与单个肌球蛋白在体外的报道相一致．
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| 关 键 词： | 单粒子追踪，活细胞，?1A-肾上腺素受体，肌球蛋白，步进，模拟 |
| 收稿时间： | 2007-05-08 |
| 修稿时间： | 2007-06-19 |
Mode of Myosin Transportation in Living Cells Studied by Single Particle Tracking |
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| Zhang-yi Liang,Ning Xu,Ying-hua Guan,You-yi Zhang and Xin-sheng Zhao. Mode of Myosin Transportation in Living Cells Studied by Single Particle Tracking[J]. Chinese Journal of Chemical Physics, 2007, 20(4): 445-448 |
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| Authors: | Zhang-yi Liang Ning Xu Ying-hua Guan You-yi Zhang Xin-sheng Zhao |
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| Affiliation: | Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China,Institute of Vascular Medicine, Peking University Third Hospital, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100083, China,Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China,Institute of Vascular Medicine, Peking University Third Hospital, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100083, China,Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China |
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| Abstract: | |
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| Keywords: | Single particle tracking Live cell ?1A-adrenergic receptor Myosin assay |
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