Steroid-responsive nephrotic syndrome in a child with juvenile idiopathic arthritis |
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Authors: | Flavio Bandin Marion Merhenberger Anne Modesto Karine Brochard Stéphane Decramer |
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Affiliation: | (1) Department of Paediatric Nephrology, Children’s Hospital, Centre de Référence du Sud-Ouest des Maladies Rénales Rares, 31059 Toulouse, France;(2) Department of Nephrology, Rangueil Hospital, Toulouse, France;(3) Laboratoire d’Anatomopathologie, Rangueil Hospital, Toulouse, France |
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Abstract: | Renal disease is rare in children with juvenile idiopathic arthritis, although a number of associated nephropathies have been
described, including mesangial glomerulonephritis. We report the presence of mesangial glomerulonephritis, revealed by a nephrotic
syndrome, in a paediatric patient with juvenile idiopathic arthritis. Short-term steroid treatment induced a rapid remission
of the nephrotic syndrome, but the presence of anti-nuclear antibodies, 1:320 in a homogeneous pattern, irregular deposits
of C1q in a renal biopsy, and a mother with episodes of cutaneous lupus suggested an uncertain renal evolution for this infant. |
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Keywords: | Juvenile idiopathic arthritis Mesangial glomerulonephritis Nephrotic syndrome C1q deposits |
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