心理危机干预对老年冠心病患者炎性因子的影响

目的探讨心理危机干预对老年冠心病患者炎性因子水平的影响。方法选择老年冠心病患者270例,分别进行焦虑自评量表(SAS)及抑郁自评量表(SDS)调查,同时检测炎性因子水平,根据是否有焦虑、抑郁症状随即分为观察组180例和对照组90例。1年后重新对以上个体进行SAS和SDS评分及高敏C反应蛋白(hs-CRP)、TNFα、白细胞介素6(IL-6)水平检测。2组患者均进行常规冠心病治疗,同时对观察组额外进行心理危机干预。结果与对照组比较,观察组干预后SAS和SDS评分明显降低(P<0.05,P<0.01)。观察组焦虑、抑郁患者干预后SAS和SDS评分较干预前明显下降,观察组下降幅度较对照组更明显(P<0.01)。观察组干预后hs-CRP、TNF-α、IL-6水平较干预前明显下降(P<0.01),且观察组较对照组下降更明显(P<0.05)。结论心理危机干预可以减轻老年冠心病患者的焦虑、抑郁症状,降低炎性因子水平,但对无焦虑、抑郁患者影响较小。

Effect of psychological crisis intervention on inflammatory factors in the elderly patients with coronary heart disease

Objective To investigate the effects of psychological crisis intervention on the level of inflammatory factors in elderly patients with coronary heart disease.Methods Elderly patients with coronary heart disease were investigated with self-rating anxiety scale(SAS) and self-rating depression scale(SDS).The levels of inflammatory factors were examined.Then they were randomly divided into the intervention group(n = 180) and the control group(n = 90).Conventional heart disease medical treatment was given to both groups,while psychological crisis intervention was given to intervention group.After a year,they were investigated with SAS and SDS and the levels of inflammatory factors were examined again.Results After a year,the scores of SAS and SDS in intervention group were significantly lower than those rated in first time(P<0.05,P<0.01),and the scores were also significantly lower than before intervention in the groups of depression and anxiety in intervention group(P<0.05).The levels of TNF-α,IL-6 and hs-CRP decreased after intervention in intervention group(P<0.01),the extent of decrease was more significant in intervention group than in control group(P<0.05).Conclusion Psychological crisis intervention could ease depression and anxiety of elderly patients with coronary heart disease and decrease the levels of inflammatory factors,but it had little effect on coronary heart disease patients without depression and anxiety.