44例5-HT3受体拮抗剂不良反应文献分析

目的探讨5-羟色胺3(5-HT3)受体拮抗剂致药品不良反应(ADR)的特点及相关因素,为临床合理用药提供参考。方法利用"维普医药信息资源服务系统"、"万方数据医药信息系统"、"中华医学会全文期刊"、"中国医院数字图书馆",以"昂丹司琼"、"格拉司琼"、"托烷司琼"、"阿扎司琼"、"雷莫司琼"、"5-HT3受体拮抗剂"等为题名进行全面搜索,对2000年1月~2011年12月国内公开报道的5-HT3受体拮抗剂所致的ADR44例进行统计分析。结果 44例ADR患者中男性20例(45.45%),女性24例(54.55%),格拉司琼发生ADR的例数最高30例(68.18%),临床主要累及皮肤及附件、心血管系统、呼吸系统等。结论临床应高度重视5-HT3受体拮抗剂的ADR,以确保安全用药。

Literature Analysis of 44 ADR Reports Induced by 5-HT3 Receptor Antagonist

Objective To explore the features and contributing factors of adverse drug reaction（ADR） induced by receptor antagonist and aims to provide reasonable suggestions in the clinical medication. Methods A statistical analysis was conducted on 44 ADR cases induced by 5-HT3 receptor antagonist, publicly reported during the years from January 2000 to December 2011. Terms like ＂Ondansetron Hydrochloride＂, ＂Granisetron Hydrochloride＂, ＂Tropisetron＂, ＂Azasetron hydrochloride＂, ＂Ramostetron Hydrochloride＂ and ＂5-HT3 receptor antagonist＂ were searched in major domestic joumals and databases, such as VIP Medical Information Resources Service System, Wanfang Data Medical Information System, Journals of Chinese Medical Association, and Chinese Hospital Digital Database. Results of all the 44 ADR patients, 20 of them are male, accounting for 45.45% and 24 of them are female, comprising 54.55%. The ADR cases induced by Granisetron Hydrochloride reach up to 30（68.18%）, and ADR was chiefly observed on skin, accessories, the cardiovascular system and the respiratory system. Conclusion High attention should be paid on the ADR related to 5-HT3 receptor antagonist in clinic in order to ensure the safe medication.