马杜拉分支菌引起下颌部真菌性足菌肿一例

目的 探讨1例真菌性足菌肿的临床病理特点、诊断、治疗及预后,并对其致病菌进行鉴定。方法 分析我科收治的1例下颌部真菌性足菌肿的临床及病理特点,进行真菌学及分子生物学鉴定。结果 该患者以下颌部肿胀、多发窦道形成、排大量黑色颗粒为主要症状,病理检查示化脓性肉芽肿性炎症,PAS染色可见大量藕节状真菌菌丝。ITS1、ITS2和D1/D2区测序结果示:病原菌与足菌肿马杜拉分支菌有最大的相似性,但相似性小于97%。结论 本病例为发生在下颌部的由马杜拉分支菌属内一新的菌种引起的真菌性足菌肿。

A case of eumycetoma on the submaxilla due to Madurella

jeetive Tolnvestigate the clinicopathological features, diagnosis, treatment, prognosis and causative agent of a case of eumycetoma on the submaxilla. Methods A case of eumycetoma diagnosed in our department was assessed for its clinical and pathological features as well as mycologic and molecular identification. Related literature was reviewed. Results The patient was primarily characterized by swelling of the submaxilla, with multiple sinuses draining many black granules. Pathologic examination revealed a pyogenic granulomatous inflammation, and a number of lotus rhizome node-like hypha were observed in tissue samples through PAS staining. Sequence analysis of multiple loci of the isolates, including ITS1, ITS2 and D1/D2, showed that it was mostly similar to Madurella mycetomatis with a homology of 97%. Conclusion This is a case of eumycetoma on the submaxilla induced by a novel species of Madurella.