宫颈癌血流动力学指标与其临床病理特征的相关性研究

目的探讨宫颈癌组织内彩色多普勒超声血流动力学指标与肿瘤临床病理特征之间的相关性。方法36例宫颈癌患者治疗前行经阴道彩色多普勒超声检查，记录肿瘤组织内超声血流指标——收缩期峰值血流速度（PSV）、阻力指数（RI），同时记录肿瘤的组织学分类、临床分期及鳞状细胞癌患者的血清鳞状细胞癌抗原（SCC—Ag）值；分析超声血流指标与肿瘤的组织学类型、临床分期及SCC—Ag值之间的关系。结果36例宫颈癌中Ⅰ期8例、Ⅱ期18例、Ⅲ期9例、Ⅳ期1例；其中鳞状细胞癌30例，腺癌及腺鳞癌共6例。不同组织学类型的宫颈癌癌组织内PSV、RI之间差异无统计学意义；而不同临床分期的宫颈癌癌组织内的PSV、RI之间的差异具有统计学意义，表现为临床分期Ⅲ／Ⅳ期者PSV较Ⅰ／Ⅱ期者高，而RI较Ⅰ／Ⅱ期者低；SCC—Ag与PSV间存在线性正相关关系（r=0．524，P〈0．05），与RI间不存在线性相关关系。结论宫颈癌组织内超声血流指标与肿瘤临床病理特征间存在相关性，具有一定的临床监测意义。

Correlative study between ultrasonic blood flow indexes and tumor clinical pathological characteristics in cervical cancer

Objective To explore the correlation between color Doppler ultrasonic blood flow indexes and tumor clinical pathological characteristics in cervical cancer. Methods Thirty-six patients with cervical cancer were examined by transvaginal uhrasonography. The peak systolic velocity （PSV） and resistance index （RI） were recorded, and the histological classification, clinical stage of tumor and SCC-Ag serum were recorded at the same time. Then the relationship among ultrasonic blood flow indexes, histological classification, clinical stage and SCC-Ag was analyzed. Results Among 36 cases, 8 cases were in stage Ⅰ ,18 cases in stage Ⅱ ,9 cases in stage Ⅲ and 1 case in stage Ⅳ. There were 30 cases of squamous cancer, 6 cases of adenocarcinoma and adenosquamous carcinoma. There was no significant difference between PSV and RI on differenct histological classification in cervical cancer, while there was significant difference between PSV and RI on different clinical stage in cervical cancer. The PSV in stage Ⅲ - Ⅳ was higher than that in stage Ⅰ - Ⅱ , and RI in stage Ⅲ - Ⅳwas lower than that in stage Ⅰ - Ⅱ . There was linear positive correlation between PSV and SCC-Ag serum （r = 0. 524,P 〈 0.05）. Conclusion There is correlation between ultrasonic blood flow indexes and tumor clinical pathological characteristics in cervical cancer, and it has important value in clinical monitoring.