诱导细胞焦亡抑制恶性肿瘤的新策略研究进展

细胞焦亡是一种非典型的细胞程序性死亡方式,其主要表现为各种外界刺激后细胞膜产生孔隙,随后细胞膨胀、胞液外流、分泌炎性因子引起炎性反应,最终导致细胞崩解.焦亡起初发现于感染性疾病,但后来在神经系统、心血管系统中均有所发现,近期研究也发现了其在肿瘤中也存在,探究其对肿瘤的作用成为研究热点之一.目前已有研究提出抗肿瘤药物、中...

New Strategies of Inhibiting Malignant Tumor Based on Inducing Pyroptosis

Pyroptosis is an atypical mode of cell programmed death,which is mainly manifested by pore formation,cell expansion,cell fluid outflow,secretion of inflammatory factors causing inflammatory response,and ultimately leading to cell disintegration after various external stimuli.Pyroptosis was first found in infectious diseases,but later found in the nervous system and cardiovascular system.Recent studies have also found that pyroptosis exists in tumors.It has become one of the hot research topics to explore its role in tumors.At present,studies have proposed that anti-cancer drugs,Chinese medicine monomers and so on can induce the pyroptosis of cancer cells.Therefore,this paper explores the impact molecules related to tumor cell pyroptosis,and summarizes its effect,then proposes two possible new strategies of preventing chemoresistance and regulating metabolic molecules.