| 基于生物方剂分析药理策略的柴胡疏肝散抗抑郁疗效质量标志物研究 |
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| 引用本文： | 吴磊,刘雅琳,黄熙. 基于生物方剂分析药理策略的柴胡疏肝散抗抑郁疗效质量标志物研究[J]. 中草药, 2021, 52(9): 2617-2625 |
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| 作者姓名： | 吴磊 刘雅琳 黄熙 |
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| 作者单位： | 南京中医药大学附属医院, 江苏 南京 210029;南京中医药大学, 江苏 南京 210029;河南中医药大学, 河南 郑州 450046 |
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| 基金项目： | 国家自然科学基金资助项目（81573797） |
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| 摘 要： | 目的 在生物方剂分析药理(bioanalytical pharmacology,BAP)策略的指导下,检测柴胡疏肝散水提物中具有抗抑郁作用的可吸收生物活性物质,为柴胡疏肝散抗抑郁疗效的质量标志物(quality marker,Q-Marker)评价提供依据.方法 运用液相色谱-串联质谱(LC-MS/MS)测定柴胡疏肝散...
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| 关 键 词： | 柴胡疏肝散 质量标志物 生物方剂分析药理策略 抑郁症 生物活性物质 |
| 收稿时间： | 2021-02-19 |
Quality markers of Chaihu Shugan Powder anti-depression effect based on bioethnopharmaceutical analytical pharmacology strategy |
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| WU Lei,LIU Ya-lin,HUANG Xi. Quality markers of Chaihu Shugan Powder anti-depression effect based on bioethnopharmaceutical analytical pharmacology strategy[J]. Chinese Traditional and Herbal Drugs, 2021, 52(9): 2617-2625 |
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| Authors: | WU Lei LIU Ya-lin HUANG Xi |
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| Affiliation: | Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China;Nanjing University of Chinese Medicine, Nanjing 210029, China;Henan University of Chinese Medicine, Zhengzhou 450046, China |
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| Abstract: | Objective To detect the antidepressant absorption active compounds in water extract of Chaihu Shugan Powder, and provide a basis for evaluation of quality marker (Q-Marker) of Chaihu Shugan Powder antidepressant effect under the guidance of bioethnopharmaceutical analytical pharmacology (BAP) strategy. Methods LC-MS/MS was used to determine the 28 compounds in water extract of Chaihu Shugan Powder. Rats were ig given Chaihu Shugan Powder, compounds in rat plasma were analyzed and biological activity substances were screened to explore Q-Marker with antidepressant effects. Results Among 28 components in water extract of Chaihu Shugan Powder, 22 components were determined to be absorbed into blood. A total of 10 biological activity substances had antidepressant effects similar to Chaihu Shugan Powder. Conclusion Paeoniflorin, ferulic acid, naringin, hesperidin, hydrated hesperidin, glycyrrhizic acid, saikosaponin A, lichenpin, hesperetin, and glycyrrhetinic acid are Q-Markers for antidepressant effect of Chaihu Shugan Powder. |
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| Keywords: | Chaihu Shugan Powder quality marker bioanalytical pharmacology strategy depression biologically active substance |
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