银杏叶提取物注射液联合奥拉西坦治疗急性脑梗死的临床研究

目的探究银杏叶提取物注射液联合注射用奥拉西坦治疗急性脑梗死的临床疗效。方法选取2016年4月—2017年11月解放军陆军第946医院收治的108例急性脑梗死患者为研究对象,全部研究对象随机分为对照组和治疗组,每组各54例。对照组静脉滴注注射用奥拉西坦,5 g溶于5%葡萄糖溶液250 mL中,1次/d。治疗组在对照组基础上静脉滴注银杏叶提取物注射液,20 mL溶于5%葡萄糖溶液250 mL中,1次/d。两组均治疗2周。观察两组的临床疗效,比较两组的国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分、血液流变学指标、血管内皮功能指标。结果治疗后,对照组和治疗组的总有效率分别为75.93%、90.74%,两组比较差异有统计学意义(P0.05)。治疗后,两组NIHSS评分、mRS评分均显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组NIHSS评分、mRS评分明显低于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组全血黏度(WBV)、纤维蛋白原(FIB)、红细胞沉降率(ESR)水平均显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组WBV、FIB、ESR水平明显低于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组一氧化氮(NO)水平显著增加,内皮素-1(ET-1)水平显著降低(P0.05);且治疗组ET-1、NO水平明显优于对照组,两组比较差异有统计学意义(P0.05)。结论银杏叶提取物注射液联合注射用奥拉西坦治疗急性脑梗死具有较好的临床疗效,可改善血液流变学指标,增强血管内皮功能,保护神经功能,具有一定的临床推广应用价值。

Clinical study on Extract of Ginkgo Biloba Leaves Injection combined with oxiracetam in treatment of acute cerebral infarction

Objective To explore the clinical effect of Extract of Ginkgo Biloba Leaves Injection combined with Oxiracetam for injection in treatment of acute cerebral infarction. Methods Patients (108 cases) with acute cerebral infarction in the 946th Hospital of PLA from April 2016 to November 2017 were randomly divided into control and treatment groups, and each group had 54 cases. Patients in the control group were iv administered with Oxiracetam for injection, 5 g added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were iv administered with Extract of Ginkgo Biloba Leaves Injection on the basis of the control group, 20 mL added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and NIHSS scores, mRS scores, blood rheology indexes, and vascular endothelial function in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 75.93% and 90.74%, respectively, and there was difference between two groups (P<0.05). After treatment, NIHSS scores and mRS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of WBV, FIB, and ESR in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the blood rheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of NO in two groups were significantly increased, but the levels of ET-1 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the vascular endothelial function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Extract of Ginkgo Biloba Leaves Injection combined with Oxiracetam for injection has clinical curative effect in treatment of acute cerebral infarction, can improve hemorheological indexes, enhance vascular endothelial function and protect its nervous function, which has a certain clinical application value.