脑电功率谱分析在波尔山羊爆炸性颅脑冲击伤评估中的应用

目的探讨脑电功率谱分析在波尔山羊爆炸性颅脑冲击伤评估中的应用。 方法试验动物为波尔山羊，共15只。采用没有破片的TNT炸药来致伤试验波尔山羊，根据试验波尔山羊脑组织病理结果将试验动物分为3组，每组5只。对照组：未致伤的健康波尔山羊；有损伤组：致伤且病理显示有脑损伤的试验波尔山羊；无损伤组：致伤且病理显示无脑损伤的试验波尔山羊。记录试验动物伤前和伤后3h的脑电图，并对比1～30 Hz频段的脑电功率谱变化。计算δ、θ、α、β四个频率的功率值和(δ＋θ)/(α＋β)值。 结果损伤组试验波尔山羊的脑电功率谱在3 Hz、4 Hz、5 Hz、6 Hz四个频率的功率值分别为(6.55±2.82)μV、(4.71±0.93)μV、(3.47±0.76)μV和(2.82±0.54)μV，对照组四个频率的功率值分别为(3.20±0.58)μV、(3.16±0.40)μV、(2.61±0.34)μV和(2.15±0.10)μV，两者比较差异有统计学意义(P值分别为0.031，0.009，0.049和0.026)。对照组的δ频段功率值为(3.20±0.99)μV，θ频段功率值为(2.27±0.64)μV，(δ＋θ)/(α＋β)值为(1.35±0.46)μV；损伤组的δ频段功率值为(9.81±1.06)μV，θ频段功率值为(4.97±1.41)μV，(δ＋θ)/(α＋β)值为(3.19±0.74)μV，与对照组比较差异有统计学意义(P值分别为0.045，0.048和0.024)。无损伤组δ频段功率值为(3.01±0.93)μV，θ频段功率值为(2.31±0.80)μV，(δ＋θ)/(α＋β)值为(1.47±0.32)μV，与对照组比较差异无统计学意义(P值分别为0.794，0.940和0.566)。 结论脑电功率谱分析可以作为现场试验脑损伤评估的一种灵活方便准确的方法。

The application of assessment of blast traumatic brain injury EEG power spectral analysis

ObjectiveTo determine whether EEG spectral analysis could be used for the analysis of animal models with blast traumatic brain injury. MethodsWe built animal traumatic model using TNT bomb without fragments.All the 15 goats were divided into 3 groups according their brain pathology change.We recorded EEG from the animals at the time before bomb exploring as well as 3 hours after blast.Then, we assessed EEG spectral differences from 1 to 30 Hz and compared EEG spectral with different groups, following with alculating the absolute power value in each band and (δ+ θ)/(α+ β) value. ResultsThe injury group′s spectral power values with 3 Hz、4 Hz、5 Hz and 6 Hz were (6.55±2.82)μV、(4.71±0.93)μV、(3.47±0.76)μV and (2.82±0.54)μV.The healthy control group′s spectral power values with 3 Hz、4 Hz、5 Hz and 6 Hz were (3.20±0.58)μV、(3.16±0.40)μV、(2.66±0.34)μV and (2.15±0.10)μV.It′s of significant difference between the two groups, the P value was 0.031, 0.009, 0.049 and 0.026. The healthy control group′s spectral value of δ band was (3.20±0.99)μV and θ band was (2.27±0.64)μV and (δ+ θ)/(α+ β) was (1.35±0.46)μV.The injury group′s spectral value of δ band was (9.81±1.06)μV and θ band was (4.97±1.41)μV and (δ+ θ)/(α+ β) was (3.19±0.74)μV, which were significantly higher than the healthy control group(P=0.045, 0.048, 0.024). The no injury group′s spectral value of δ band was (3.01±0.93)μV and θ band was (2.31±0.80)μV and (δ+ θ)/(α+ β) was (1.47±0.32)μV, which were similar with the healthy control group (P=0.794, 0.940, 0.704). ConclusionEEG power spectral analysis can be used as a flexible tool to demonstrate the animal model with traumatic brain injury.