| 载羟基喜树碱纳米粒的制备和体外评价 |
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| 引用本文： | 刘占军,李晓春,赵鸣飞,韩刚.载羟基喜树碱纳米粒的制备和体外评价[J].中国医院药学杂志,2015,35(21):1910-1914. |
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| 作者姓名： | 刘占军 李晓春 赵鸣飞 韩刚 |
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| 作者单位： | 1. 华北理工大学药学院, 河北 唐山 063000;
2. 陕西省食品药品检验所, 陕西 西安 710061;
3. 华北理工大学公共卫生学院, 河北 唐山 063000 |
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| 基金项目： | 河北省自然科学基金——石药集团医药联合研究基金优先资助项目(编号:H2013209192) |
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| 摘 要： | 目的:制备壳寡糖接枝布洛芬(COS-g-IBU)纳米粒负载羟基喜树碱(HCPT)纳米粒,并考察其体外释药性能。方法:以1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐(EDC)为偶联剂,制备壳寡糖接枝布洛芬纳米粒(COS-g-IBU NPs)。以COS-g-IBU NPs为载体,使用超声振荡技术制备负载HCPT的壳寡糖接枝布洛芬纳米粒(HCPT-COS-g-IBU NPs)。结果:透射电镜照片显示COS-g-IBU NPs和HCPT-COS-g-IBU NPs为球形,平均粒径分别为(116±2)nm和(146±5)nm,测得药物包封率为(79.24±1.18)%,载药量为(3.62±0.05)%,体外药物释放试验表明HCPT-COS-g-IBU NPs具有明显的缓释作用。结论:COS-g-IBU可作为HCPT缓释载体材料。
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| 关 键 词： | 羟基喜树碱 壳寡糖 布洛芬 纳米粒 |
| 收稿时间： | 2014-11-03 |
Preparation and in vitro evaluation of nanoparticles loaded with 10-hydroxycamptothecin |
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| LIU Zhan-jun,LI Xiao-chun,ZHAO Ming-fei,HAN Gang.Preparation and in vitro evaluation of nanoparticles loaded with 10-hydroxycamptothecin[J].Chinese Journal of Hospital Pharmacy,2015,35(21):1910-1914. |
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| Authors: | LIU Zhan-jun LI Xiao-chun ZHAO Ming-fei HAN Gang |
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| Affiliation: | 1. School of Pharmacy, North China University of Science and Technology, Hebei Tangshan 063000, China;
2. Shaanxi Institute for Food and Drug Control, Shaanxi Xi'an 710061, China;
3. School of Public Health, North China University of Science and Technology, Hebei Tangshan 063000, China |
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| Abstract: | OBJECTIVE To prepare chitosan-oligosaccharide-graft-ibuprofen (COS-g-IBU) loaded with 10-hydroxycamptothecin (HCPT), and investigate its in vitro release properties.METHODS Chitosan oligosaccharide grafted ibuprofen nanoparticles (COS-g-IBU NPs) was synthesized with 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (EDC) as coupling agent. HCPT-COS-g-IBU NPs were prepared by ultrasonic irradiation technology.RESULTS TEM images showed that COS-g-IBU NPs and HCPT-COS-g-IBU NPs were spheres with mean sizes of (116±2) nm and (146±5) nm, respectively. Encapsulation efficiency of nanoparticles was up to (79.24±1.18)%; and the drug loading was (3.62±0.05)%.CONCLUSION COS-g-IBU can be used as a sustained release carrier material for HCPT. |
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| Keywords: | 10-hydroxycamptothecin chitosan oligosaccharide ibuprofen nanoparticles |
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