结直肠肿瘤中长链非编码RNA的研究进展

近年来许多长链非编码RNA(lncRNA)被发现,lncRNA表达量的异常与肿瘤的发生、发展密切相关,根据其作用可以分为促进肿瘤作用lncRNA和抑制肿瘤作用lncRNA,lncRNA普遍高表达于实体肿瘤内部,是参与肿瘤侵袭、增殖和转移的重要因素,且与肿瘤预后有关。本文介绍了目前lncRNA的研究现状,着重讲述了当前研究较为透彻的几个lncRNA(如:HOTAIR、H19、MALAT-1、LincRNA-p21、GAS5等)的功能及其在结直肠肿瘤组织中的表达情况,提示调控lncRNA表达量可能为结直肠肿瘤的诊断和治疗提供新的依据。

Progress in long non-coding RNA of colorectal cancer

Many long non-coding RNA(lncRNA)has been found in recent years.The abnormal lncRNA expression is closely related to the occurrence and development of tumor.LncRNA can be divided into the tumor promoting and tumor inhibiting according to the function.lncRNA generally overexpresses in solid tumor tissue,acts as an important factor involved in tumor invasion,proliferation and metastasis,and has been associated with prognosis of neoplasm.This paper describes the current situation of lncRNA research.We mainly introduce several functions of lncRNA which thoroughly researched at present(such as HOTAIR,H19,MALAT-1,LincRNA-p21,GAS5,etc)and their expression in colorectal tumor tissue,indicating that regulating the expression level of lncRNA may provide a new basis for the diagnosis and treatment of colorectal cancer.