化胃舒颗粒体内抗肿瘤作用的实验研究

摘要: 目的探讨化胃舒颗粒对小鼠移植性肿瘤的抑制作用。方法以S180 肉瘤和H22 肝癌作为实验瘤株，观察化胃 舒颗粒对S180 小鼠肉瘤的抑瘤率及对H22 肿瘤小鼠生存期的影响。采用小鼠移植性肿瘤S180 实体瘤模型，观察化胃舒 颗粒与环磷酰胺( CTX) 联用对S180 实体瘤小鼠的白细胞数及抑瘤率的影响。结果化胃舒颗粒能阻止S180 肿瘤生长， 小鼠肿瘤抑制率在30%以上; 化胃舒颗粒能明显延长H22 肿瘤小鼠的生存时间; 化胃舒颗粒能抑制由环磷酰胺( CTX) 引 起的S180 实体瘤小鼠血液中白细胞总数的减少，从而增强环磷酰胺( CTX) 的抑瘤作用。结论化胃舒颗粒对S180 肉瘤 和H22 肝癌荷瘤小鼠有明显的抗肿瘤作用，与环磷酰胺( CTX) 合用有显著的减毒增效作用。

Experimental Study on Anti-tumor Effect of Huaweishu Granule in vivo

Abstract: Objective To study the inhibitory effects of Huaweishu granule on mice transplanted tumors． Method The S180-mice model was used to observe the tumor-inhibition rate of Huaweishu granule and the H22-mice model was used to test the survival time． To observe the effect of Huaweishu granule with combination of CTX on WBC and tumor weight of S180-mice model． Result Huaweishu granule had the inhibitory effects on tumor cell growth of S180-mice and the inhibitory ratio of Huaweishu granule in S180- mice was 30% above; Huaweishu granule combined with CTX could reduce the number of WBC in S180 tumor-bearing mice and improve the antitumor effects of CTX． Conclusion Huaweishu granule has potent inhibitory effect on the growth of implanted S180 and H22 in mice and has synergetic effect and attenuated toxic effect in combination with CTX．