| 肝素对微血栓大鼠作用的实验研究 |
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| 引用本文： | 郭渝成,曾祖荫,张志高,葛苹菊,金惠铭,杨诗春,张国平,刘信桥.肝素对微血栓大鼠作用的实验研究[J].西南国防医药,1995(2). |
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| 作者姓名： | 郭渝成 曾祖荫 张志高 葛苹菊 金惠铭 杨诗春 张国平 刘信桥 |
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| 作者单位： | 解放军44医院，解放军44医院，解放军44医院，解放军44医院，上海医科大学病生教研室，上海医科大学病生教研室，上海医科大学病生教研室，上海医科大学病生教研室 贵阳 550009，贵阳 550009，贵阳 550009，贵阳 550009 |
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| 摘 要： | 经静脉注射高分子右旋糖酐,复制循环微血栓及心电图表现异常的大鼠模型,观察肝素对微血栓的治疗作用。结果发现,肝素治疗组心电图改善,血粘度下降,循环微血栓数目减少,心肌细胞膜上Na~ —K~ —ATP酶活性较盐水对照组略有上升,但统计学上无显著差异。提示肝素可减少实验动物循环血中微血栓的形成,改善心电图异常变化,但心肌细胞膜的Na~ —K~ —ATP酶活性恢复较慢。
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| 关 键 词： | 微血栓 肝素 心肌细胞 Na~ -K~ -ATP酶 |
EFFECT OF MICROTHROMBUS ON HEART AND TREATMENT OF HEPARIN FOR MICROTHROMBUS |
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| Guo Yucheng,Zong Zuying,Zhang Zhigao et al.EFFECT OF MICROTHROMBUS ON HEART AND TREATMENT OF HEPARIN FOR MICROTHROMBUS[J].Medical Journal of National Defending forces in Southwest China,1995(2). |
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| Authors: | Guo Yucheng Zong Zuying Zhang Zhigao |
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| Affiliation: | Guo Yucheng,Zong Zuying,Zhang Zhigao et al.
The Hospital of PLA,Guiyang 550009. |
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| Abstract: | A microthrombus and abnormal ECG rat model was reproduced through the intravenous injection of macromolecular dextran. The treatment of heparin for microthrombus in the circulation had been studied. The results showed that ECG of the animals of heparin group improved, their blood viscosity and the number of the microthrombus in the circulation decreased. Compared with the control group, the activity of Na -K - ATP ase on the cardiac muscle cellular membrane increased a little, but the difference between two groups was not significant (P>0. 05). therefore, it was suggested that heparin eliminate the microthrombus from the circulation of the model and prevent the ECG ab-nomality, but have a little effect on the recovery of the activity of Na -K - ATP ase on the cardiac muscle cellular membrane. |
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| Keywords: | microthrombus heparin circulation treatment |
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