苯氧乙醇标准物质的纯度分析方法及不确定度评定

采用质谱(MS)和核磁共振谱(NMR)对原料苯氧乙醇进行定性分析,优化并建立了液相色谱法及气相色谱法测定苯氧乙醇,纯度为99.3％.以甲醇为基体溶液,采用重量-容量法制备苯氧乙醇标准物质.以液相色谱(紫外法、示差法)两种方法进行定值,并做了均匀性检验和稳定性跟踪.建立不确定度评定方法,标准物质特性值为99.3(±1.1) μg/mL(k=2).苯氧乙醇标准物质具有溯源性和准确性,对于化妆品中防腐剂苯氧乙醇含量的准确测定及监控具有重要意义.

Certification and Uncertainty Evaluation of Phenoxyethanol Purity Certified Reference Material

GC-MS and NMR were used to confirm the structure of phenoxyethanol.HPLC and GC were used to determine the purity of phenoxyethanol,and the purity was revealed to be 99.3％.Phenoxyethanol reference was prepared in methanol according to weight-capacity method.Ultraviolet and differential spectrophotometry were used for certificating the value,the homogeneity and stability.The uncertainty of this evaluation method was established.The property value of phenoxyethanol was 99.3 (+ 1.1) μg/mL(k =2).The standard phenoxyethanol reference prepared in this study was traceable and accurate,and it can be used as a standard reference for preservative analysis of cosmetics.