| PBS/PLA胸骨可降解材料组织相容性实验研究 |
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| 引用本文： | 华琨,王小威,张维,周建,杨秀滨,季君晖.PBS/PLA胸骨可降解材料组织相容性实验研究[J].第三军医大学学报,2010,32(20). |
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| 作者姓名： | 华琨 王小威 张维 周建 杨秀滨 季君晖 |
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| 作者单位： | 1. 北京协和医学院中国医学科学院阜外心血管病医院心脏外科,北京,100037
2. 中国科学院理化技术研究所,北京,100190 |
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| 基金项目： | 国家自然科学基金(30870620)~~ |
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| 摘 要： | 目的通过与聚乳酸(polylactic acid,PLA)进行对比,了解聚丁二酸丁二醇类聚酯poly(butyl succinate),PBS]/聚乳酸(PLA)合金材料植入动物体内后组织相容性情况。方法选取60只SPF级SD大鼠,按随机数字表法分为4组:Sham组、PBS/PLA组、PBS组和PLA组,每组15只。每只大鼠背部做1个切口,PBS组植入单纯PBS材料,PBS/PLA组植入PBS/PLA合金材料,PLA组植入PLA材料,Sham组切开皮肤后立即缝合,不做其他处理。植入后1、4、8、12、16周后,实验组切取包裹材料的皮下组织,对照组切取切口处皮下组织。主要观察指标:观察切口大体表现;HE染色后光学显微镜观察组织中性粒细胞、淋巴细胞浸润程度和毛细血管密度;Masson染色观察材料周围纤维包裹程度;TUNEL法光镜观察材料对皮下组织凋亡情况。结果第1、4、8、12、16周结果提示PBS/PLA组与PBS组和PLA组相比,3组材料引起的局部炎性细胞浸润和淋巴细胞相似,组织急慢性炎症反应无明显差异;纤维包裹程度PBS/PLA组介于PBS组和PLA组之间(P<0.05);对于材料引起的局部组织细胞凋亡反...
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| 关 键 词： | 聚丁二酸丁二醇 聚乳酸 胸骨固定 组织相容性 |
Histocompatibility of PBS/PLA blend as sternal fixation apparatus in rats |
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| Hua Kun,Wang Xiaowei,Zhang Wei,Zhou Jian,Yang Xiubin,Ji Junhui.Histocompatibility of PBS/PLA blend as sternal fixation apparatus in rats[J].Acta Academiae Medicinae Militaris Tertiae,2010,32(20). |
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| Authors: | Hua Kun Wang Xiaowei Zhang Wei Zhou Jian Yang Xiubin Ji Junhui |
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| Affiliation: | Hua Kun1,Wang Xiaowei2,Zhang Wei2,Zhou Jian1,Yang Xiubin1,Ji Junhui2(1Department of Cardiac Surgery,Cardiovascular Institute & Fuwai Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100037,2Institute of Physics and Chemistry,Chinese Academy of Sciences,100190,China) |
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| Abstract: | Objective To investigate the in vivo sternal fixation of poly(butyl succinate)(PBS)and polylactic acid(PLA)alloy material by comparing its biocompatibility of polylactic acid(PLA).MethodsSixty SD rats were randomized into 4 groups(n=15).PBS,PLA and PBS/PLA alloy were implanted subcutaneously in the corresponding rat dorsum respectively.Sham group was designed as the control group without any material implantation.In 1,4,8,12 and 16 weeks after implantation,the implanted materials and the surrounding tissues... |
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| Keywords: | biocompatibility poly(butyl succinate) polylactic acid sternal fixation |
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