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| 甲泼尼龙治疗重症肌无力的疗效 | |
| 引用本文： | 董礼全,徐东,马春燕,崔彬,彭忠民. 甲泼尼龙治疗重症肌无力的疗效[J]. 中国新药与临床杂志, 2007, 26(6): 449-451 |
| 作者姓名： | 董礼全 徐东 马春燕 崔彬 彭忠民 |
| 作者单位： | 1. 山东大学山东省立医院,神经内科,山东济南250021 2. 山东大学山东省立医院,中心实验室,山东济南250021 3. 山东大学山东省立医院,胸外科,山东济南250021 |
| 摘 要： | 目的:评价甲泼尼龙治疗重症肌无力(MG)的临床效果。方法:对大剂量甲泼尼龙冲击(MPPT)治疗的34例MC病人于治疗前及治疗后分别进行临床评分,乙酰胆碱受体抗体(AChRAb)滴度,CD4~+CD25~+调节性T细胞(CD4~+CD25~+Tr)数量检测。结果:MPPT治疗MG后,1wk时临床显效率56%,3 mo时临床显效率为79%,总有效率为91%。治疗3mo后血清AChRAb滴度无明显变化(P＞0．05),CD4~+CD25~+Tr百分率明显升高,与治疗前相比差别有非常显著意义(P＜0．01)。结论:甲泼尼龙治疗重症肌无力的疗效好,可促进CD4~+CD25~+Tr细胞比率升高,值得临床推广。 |
| 关 键 词： | 甲泼尼龙 重症肌无力 受体,胆碱能 T淋巴细胞 |
| 文章编号： | 1007-7669（2007）06-0449-03 |
| 收稿时间： | 2006-11-10 |
| 修稿时间： | 2006-11-102007-04-26 |
Therapeutic effect of methylprednisolone on myasthenia gravis |
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| DONG Li-quan,XU Dong,MA Chun-yan,CUI Bin,PENG Zhong-min. Therapeutic effect of methylprednisolone on myasthenia gravis[J]. Chinese Journal of New Drugs and Clinical Remedies, 2007, 26(6): 449-451 | |
| Authors: | DONG Li-quan XU Dong MA Chun-yan CUI Bin PENG Zhong-min |
| Affiliation: | a.Department of Neurology; b.Centr-laboratory; c.Chest Surgery Department, Shandong Provincial Hospital, Shandong University, Ji-nan SHANDONG 250021, China |
| Abstract: | AIM:To evaluate the therapeutic effect of methylprednisolone pulse therapy (MPPT) on myasthenia gravis(MG).METHODS:Thirty-four patients with definite MG were treated by high dosage MPPT.Before and after treatment,the clinical scores,acetylcholine receptor antibody (AChRAb) titers,and the expression of CD4~+CD25~+Tr cells were measured.RESULTS:One week after MPPT treatment,the clinical therapeutic rate reached 56% and increased to 79% three months later,with total effective rate of 91%. AChRAb titers showed no markedly change (P＞0.05).The expression of CD4~+CD25~+Tr cells demonstrated high significant in comparing with that before the treatment (P＜0.01).CONCLUSION:The treatment effect of methylprednisolone therapy on myasthenia gravis is positively efficient with promotion of the expression of CD4~+CD25~+Tr cells and worthy to reommended clinically. |
| Keywords: | methylprednisolone myasthenia gravis receptors, cholinergic T-lymphocytes |
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