基于关联规则的中药组分配伍治疗脑缺血再灌注损伤规律研究

目的探讨治疗脑缺血再灌注损伤(cerebral ischemia reperfusion injury,CIRI)的高频用药,并揭示用药与证型、组分与组分的关系,从组分层面解析中药治疗CIRI的配伍规律。方法收集中国知网(1998-08-25至2018-08-25)20年期刊文献数据库中治疗CIRI的中药及相关组分的研究,采用关联规则Apriori计算方法,对治疗CIRI的中药复方及相关组分的研究结果进行挖掘分析。结果高频次药物包括补阳还五汤、川芎嗪注射液、黄芪提取物等,印证及推测出构成丹参、三七等单味中药的活性成分及血栓通注射液和脑心通胶囊等中药复方的药效物质基础,并发现了芍药苷-阿魏酸、黄芪甲苷-藁本内酯-阿魏酸等新的组分配伍形式。结论基于关联规则,为CIRI中药组分配伍治疗挖掘高频用药、用药与证型、组分与组分的关联关系,可为组分配伍研发提供依据与参考。

Study on Component Compatibility Regularity of Chinese Medicine in Treatment of Ischemia Cerebral Reperfusion Injury Based on Association Rules

Objective To explore the high frequency Chinese medicine for ischemia cerebral reperfusion injury(CIRI), reveal the relationship between the medication and syndromes, and different components, and analyze the component compatibility regularity of Chinese medicine in the treatment CIRI from component level. Methods The research on the Chinese medicine and related components for treating CIRI in the CNKI(1998-08-25 to 2018-08-25) 20-year periodical literature database were collected, and the association rule Apriori algorithm was used to perform mining analysis of the research results of Chinese medicine for CIRI and its related components. Results The high-frequency drugs included Buyang Huanwu Decoction, Ligustrazine Injection,Radix Astragali seu Hedysari Extract, etc., which confirmed and speculated the active ingredients that made up the single Chinese medicine such as Radix Salviae Miltiorrhizae and Radix Notoginseng, and medicinal effect base of Chinese medicine compound such as Xueshuantong Injection and Naoxintong Capsule, and found new groups of compatibility such as paeoniflorinferulic acid, astragaloside-4, ligustilide-ferulic acid, etc. Conclusion Based on the association rules, this paper explores the highfrequency medications, medications and syndrome types, component and component associations for the Chinese medicine component compatibility in the treatment of CIRI, which can provide basis and references for the development of component compatibility research.