淋巴瘤患者症状评估量表的编制及信效度检验

目的：拟根据淋巴瘤疾病特异性症状及各种治疗反应，编制适用于淋巴瘤患者的症状评估量表，并检验其信效度。方法：在查阅文献、半结构式访谈及现有的癌症患者多症状评估工具基础上总结淋巴瘤患者症状条目池；通过两轮专家函询，形成淋巴瘤患者症状评估表。采用淋巴瘤患者症状评估表及M.D.安德森症状评估量表对150例治疗前、治疗中的患者进行评估，检验其量表的信效度。 结果：淋巴瘤患者症状评估量表包括23个条目，各症状条目的I-CVI在0.750-1.000之间，量表内容效度的S-CVI/Ave为0.900；探索性因子分析提取6个公因子，其方差累积贡献率为69.63%，分别将其命名为胃肠道反应、其它副作用、疾病全身症状、情绪-睡眠、疼痛相关症状、皮肤反应6个维度；以MDASI-PartII作为效标工具，淋巴瘤患者症状评估量表总分与MDASI-Partll总分相关系数r为0.688，P＜0.001。总量表的Cronbach’s α系数为0.812，6个公因子Cronbach’s α系数0.770-0.899。结论：此次研究形成的淋巴瘤患者症状评估表具有较好的信效度，适用于淋巴瘤患者症状的测评。

Developmentand validation of symptom assessment scale for lymphoma patients

Objective: To develop an instrument of lymphoma symptom assessment and to test its reliability and validity based on the specific symptoms of lymphoma and various therapeutic responses.Methods:Based on literature review, semi-structured interviews and existing symptom assessment tools of cancer patients, the item pool of patients with lymphoma were summarized. Through two rounds of expert interrogation, lymphoma symptom assessment scale was established. 150 patients with pre-treatment and in-treatment were evaluated using the lymphoma symptom assessment scale and the M.D. Anderson symptom assessment scale, for testing the validity and reliability. Results: The lymphoma symptom assessment scale included 23 items, the I-CVI for each symptom entry ranged from 0.750 to 1.000 and the S-CVI / Ave for the content-validity of the scale was 0.900; exploratory factor analysis extracted 6 common factors, the cumulative contribution rate was 69.63% .There were 6 dimensions named gastrointestinal tract reactions, other side effects, systemic symptoms, mood-sleep, pain-related symptoms, skin reactions. Using MDASI-PartII as the benchmarking tool, the total score of the assessment scale and the MDASI-Partll score were statistically significant with a correlation coefficient of 0.688(P<0.01). The total scale Cronbach’s coefficient was 0.812; Cronbach’s coefficient of 6 common factors ranged from 0.770 to 0.899. Conclusion: Thelymphoma symptom assessment scale has good reliability and validity, which can be used as a tool to assess the symptoms of lymphoma patients.