非胰岛素依赖型糖尿病患者血清唾液酸的改变

测定20例NIDDM伴有心脑血管病变的患者、20例单纯NIDDM患者的血清唾液酸（SA）水平，并与20例正常人进行比较。结果发现所有NIDDM患者的血清SA水平均显著增高（P＜0．01），其中伴有心脑血管疾病患者的血清SA水平显著高于单纯NIDDM患者（P＜0．05），同时血清SA水平与血清胰岛素及C肽水平、收好压之间存在相关。提示血清SA水平与NIDDM患者的心脑血管疾病关系密切，可能是心脑血管并发症发生的一个危险因素。

Changes of the Serum Sialic Acid in Non-insulin Dependent Diabetes Mellitus Patients

The serum sialic acid level was determined in 20 NIDDM patients with cardio-cerebral vflscular disease, in 20 simple NIDDM patients and also in 20 normal subjects for comparison. The results showed that the serum sialic acid level was significantly higher in all NIDDM patients (P<0. 01 ). The level in NIDDM patients with cardio-cerebral vascular disease was significantly higher than in simple NIDDM patients (P<0. 05). Meanwhile the serum sialic acid level was significantly correlated with serum insulin, C-peptide level and systolic blood pressure. Above results suggest that the serum sialic acid level is closely related to cardio-cerebral vascular disease in NIDDM patients and rnay be a signal of risk factor of the occurrence of cardio-cerebral vascular complication.