| 心肌缺血后处理研究进展 |
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| 引用本文： | 邱清艳,秦俭.心肌缺血后处理研究进展[J].心血管病学进展,2009,30(6). |
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| 作者姓名： | 邱清艳 秦俭 |
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| 作者单位： | 重庆医科大学附属第一医院心血管内科,重庆,400016 |
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| 摘 要： | 缺血后处理是在长时间缺血后再灌注早期对心脏进行数次短暂的再灌注/缺血处理的方法。它是缺血心脏有效的内源性保护现象,可以减轻缺血/再灌注后心肌坏死与功能障碍,减少恶性心律失常的发生。人们对其发生机理、信号通路以及潜在的临床应用等方面已作了较多研究。现对缺血后处理的特征、心肌保护作用、分子机制以及临床应用前景作一综述。
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| 关 键 词： | 缺血后处理 缺血/再灌注损伤 心肌保护 |
Progress in Myocardial Ischemic Postconditioning |
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| QIU Qing-yan,QIN Jian.Progress in Myocardial Ischemic Postconditioning[J].Advances in Cardiovascular Diseases,2009,30(6). |
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| Authors: | QIU Qing-yan QIN Jian |
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| Affiliation: | QIU Qing-yan; QIN Jian(Department of Cardiology; The First Affiliated Hospital of Chongqing Medical University; Chongqing 400016; China); |
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| Abstract: | Ischemic postconditioning (I-postC) is defined as a procedure of rapid intermittent periods of reperfusion and ischemia in the early phase of reperfusion after long ischemia. I-postC is the endogenous protective mechanism capable of protecting the myocardium from myocardial necrosis, dysfunction, and vicious ventricular arrhythmia induced by ischemia/reperfusion (I/R) injury. Research has been done on its mechanism, signaling pathways, and potential clinical applications. This review will cover the characteristics, cardioprotective effects, molecular mechanism, and potential applications of I-postC. |
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| Keywords: | ischemic postconditioning ischemia/reperfusion injury myocardial protection |
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