| 手性叠氮呋喃酮及其三唑类化合物的合成 |
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| 引用本文： | 朱石嶙,马银剑,杨金会,李学强.手性叠氮呋喃酮及其三唑类化合物的合成[J].合成化学,2007,15(6):744-747,750. |
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| 作者姓名： | 朱石嶙 马银剑 杨金会 李学强 |
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| 作者单位： | 1. 宁夏大学,能源化工重点实验室,天然产物药物开发中心,化学化工学院,宁夏,银川,750021;宁夏医学院,继续教育处,宁夏,银川,750021
2. 宁夏大学,能源化工重点实验室,天然产物药物开发中心,化学化工学院,宁夏,银川,750021 |
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| 基金项目： | 国家自然科学基金资助项目(20562010)，国家重点基础研究发展计划资助项目(2007CB21602)，教育部科技研究重点资助项目(203143)，宁夏自然科学基金资助项目(NZ0606) |
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| 摘 要： | 合成了手性叠氮2(5H)-呋喃酮化合物(3a～3d);3b与含活泼亚甲基化合物发生偶极环加成反应,合成了带手性丁烯内酯的1,2,3-三唑化合物(8b和8b)。3,7和8的结构经1HNMR,13CNMR,IR和HR-MS表征。探讨了合成反应的机理。
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| 关 键 词： | 手性2(5H)-呋喃酮 叠氮化合物 三唑类化合物 偶极环加成反应 合成 |
| 文章编号： | 1005-1511（2007）06-0744-04 |
| 收稿时间： | 2007-08-20 |
| 修稿时间： | 2007-08-20 |
Synthesis of Chiral Azidofuranon and Its Triazole Compounds |
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| ZHU Shi-lin,MA Yin-jian,YANG Jin-hui,LI Xue-qiang.Synthesis of Chiral Azidofuranon and Its Triazole Compounds[J].Chinese Journal of Synthetic Chemistry,2007,15(6):744-747,750. |
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| Authors: | ZHU Shi-lin MA Yin-jian YANG Jin-hui LI Xue-qiang |
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| Affiliation: | Key Laboratory of Energy Sources and Chemical Engineering, Development Center of Products and Medication; Department of Chemistry and Chemical Engineering, 1. Ningxia University, Yinchuan 750021, China; 2. Department of Continuous Education, Ningxia Medicinal College, Yinchuan 750021, China |
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| Abstract: | Chiral azidofuranon compounds(3a~3d) were synthesized. The triazole compounds(7b and 8b) were obtained by dipolar-cycloaddition reaction from 3b and some carbonyl nucleophilic reagents containing active methylene. The structures were identified by 1H NMR, 13C NMR, IR and HR-MS. The reaction mechanism was discussed. |
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| Keywords: | chiral 2(5H)-furanon chiral azidofuranon compounds triazole compounds dipolar-cycloaddition reaction synthesis |
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